xRead - Nasal Obstruction (September 2024) Full Articles

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476

International consensus statement on rhinosinusitis

Normal

Increased

Increased

Increased

Normal

Increased

Increased

Innate

Immunity Activity

percentage of fibroblasts ((FSP + MUC1 + KI67 + cells) inCRSwNP.

percentage of fibroblasts ((Vimentin + α -SMA + cells) in

It showed an increased percentage of Wnt3a +

Flow cytometry analysis Tissue ILC2s ILC2s are highly elevated in nasal polyp tissue.

Serum specimens Cell counts Blood basophils No significant difference was observed in blood basophils between CRSwNP and controls. Nasal lavage fluids FACS Basophils of nasal secretion

NP tissue from patients with CRSwNP.

observed in basophils of nasal secretion between CRSwNP and controls.

fibroblasts from patients with CRSwNP. It showed an increased

IHC Tissue fibroblast The number of fibroblast was significantly higher in CRSwNP compared with control. FACS Sinonasal explant

It showed an increased

Type of Innate Immunity Findings

No significant difference was

Tissue fibroblast (Vimentin + α -SMA + cells)

human sinonasal fibroblast;

proliferation

fibroblast culture

Human sinonasal

Immunofluorescence FACS RT-PCR

Study Year Study Groups (size) Tissue Technique Basophils Veloso-Teles 1462 2019 CRSwNP (37)

ALI

IHC

FACS

Nasal tissue

Nasal polyps

Blood

Sinus tissue explants

Nasal tissue

Nasal polyps

Nasal tissue

Nasal polyps

Nasal tissue

Nasal polyps

Takahashi 818 2017 CRSsNP (33)

Dobzanski 1474 2018 CRSwNP (9)

CRSwNP (45) AER(13)

Control (24)

Control (25)

CRSwNP (13)

Control (24)

Control (34)

Park 825 2017 CRSsNP (20)

CRSwNP (20)

Control (10)

Carroll 826 2016 CRSwNP (15)

Control (12)

lnnate Lymphoid Cells (ILCs) Mjösberg 1478 2011 CRSwNP (4) Control (4)

Carroll 826 2016 CRSsNP (22)

TABLE X-12 (Continued)

Fibroblast