xRead - Nasal Obstruction (September 2024) Full Articles

20426984, 2021, 3, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/alr.22741 by Stanford University, Wiley Online Library on [01/07/2024]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License

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Orlandi et al.

(Continues)

Innate Immunity Activity Increased

compared to the control uncinate. Sinoasal tissue Nasal polyps ELISA Tissue IL-25 IL-25 was not elevated in NPs. Normal Xu 829 2016 CRSsNP (12) CRSwNP (35) Control (12) Sinoasal tissue Nasal polyps RT-PCR IHC Increased Lam 1413 2015 CRSsNP (12) Increased Ozturan 828 2016 CRSsNP (20) CRSwNP (20) Control (20)

H&E staining IHC RT-PCR Tissue IL-25 IL-25 was not elevated in NPs. Normal Increased

Increased

Increased

Sinoasal tissue Nasal polyps ELISA Tissue IL-25 IL-25 mRNA level was significantly higher in the CRSwNP group compared to the control. Sinoasal tissue Nasal polyps

H&E staining IHC RT-PCR Tissue IL-25 IL-25 protein level was significantly higher in the CRSwNP group compared to the control.

H&E staining IHC Tissue IL-25 IL-25 protein level was significantly higher in the CRSwNP group compared to the control.

RT-PCR IHC Tissue IL-25 The mRNA and protein levels of IL-25 were significantly elevated in polyp tissues

Tissue IL-25 IL-25 mRNA level was significantly higher in the CRSwNP group compared to the control.

RT-PCR IHC Tissue IL-25 The mRNA level of IL-25 were significantly elevated in CRSwNP (Eos and Non-Eos) as compared to the control.

Type of Innate Immunity Findings

Study Groups (size) Tissue Technique

Sinoasal tissue Nasal polyps

Sinoasal tissue Nasal polyps

Nasal tissue

Nasal polyps

Nasal polyps

Epithelia cells

Non-Eos CRSwNP (33) Control (28)

Liao 1500 2015 Eos CRSwNP (28)

TABLE X-13 Epithelial-derived innate cytokines in CRSwNP Study Year IL-25 Dogan 1498 2019 CRSwNP (33) Control (29) Nagata 1461 2019 ECRS (22) nECRS (11) Control (6) Ogasawara 1499 2019 CRSwNP (46) AERD(23)

Hong 162 2018 CRSsNP (20)

Control (34)

CRSwNP (20) Control (7)

CRSwNP (90) Control (16)