xRead - Nasal Obstruction (September 2024) Full Articles

20426984, 2021, 3, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/alr.22741 by Stanford University, Wiley Online Library on [01/07/2024]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License

480

International consensus statement on rhinosinusitis

Innate Immunity Activity Increased

Increased

Normal

Increased

Increased

Increased

Sinoasal tissue Nasal polyps ELISA Tissue TLSP TLSP mRNA levels was significantly higher in the CRSwNP group compared to the control. Nasal tissue Nasal polyps Nasal polyps

RT-PCR Tissue TLSP There was no difference between CRSwNP and control in terms of the tissue TSLP. IHC Tissue TLSP TSLP protein levels were

RT-PCR IHC Tissue TLSP The mRNA level of IL-TLSP were significantly elevated in Eos CRSwNP but not Non-Eos CRSwNP compared to the control. RT-PCR ELISA

RT-PCR IHC Tissue TSLP The mRNA level, but not protein level of TSLP were significantly elevated in polyp tissues as

compared to the control uncinate.

significantly increased in NP tissue from patients with

CRSwNP compared with control subjects.

significantly increased in CRSwNP compared with control.

Tissue TSLP TSLP mRNA levels were

Type of Innate Immunity Findings

Study Groups (size) Tissue Technique

Epithelia cells

Nasal tissue

Nasal polyps

Nasal tissue

Nasal polyps

Nasal tissue

Nasal polyps

Epithelia cells

Non-Eos CRSwNP (33) Control (28)

Nagarkar 833 2013 CRSsNP (60)

Hong 162 2018 CRSsNP (20)

Boita 834 2011 CRSsNP (5)

Dogan 1498 2019 CRSwNP (33)

Control (29)

Liao 1500 2015 Eos CRSwNP (28)

Lam 831 2012 CRSsNP (18)

CRSwNP (12) Control (7)

CRSwNP (90) Control (16)

CRSwNP (86)

Control (47)

CRSwNP (10) Control

TABLE X-13 (Continued) Study Year TSLP