xRead - Nasal Obstruction (September 2024) Full Articles

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Orlandi et al.

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Delivery Method of Corticosteroid Clinical Endpoint Conclusions Corticosteroid via nasal irrigation SNOT22 Endoscopic score SF36 Self Rating Anxiety Scale Self rating Depression Scale SNOT22 and endoscopic scores improved similarly. SF36, SAS, and SDS no changes. Corticosteroid Symptoms SNOT22 SF36

Greater change in SNOT22, lower

endoscopic scores in corticosteroid

irrigation group.

At the 12 week minimum, no difference between groups.

endoscopic scores in

budesonide irrigation group.

lower endoscopic and

radiology score when

delivered by irrigation compared to delivery by spray.

Lower SNOT22 and

Reduced symptoms,

Impressions Scale

RSDI, UPSIT, PEA test

SNOT22

Endoscopic Score Clinical Global

SNOT-22, RSOM-31,

SNOT22

Endoscopic Score Need for ESS

Endoscopic Score Radiology score

Corticosteroid via nasal irrigation

Corticosteroid via nasal irrigation

Corticosteroid via nasal irrigation

irrigation vs INCS

as double placebo

Budesonide or placebo (30days)

mg/daily as divided dose 60 mL lavage

(each nose) twice daily

Variable duration 12-24 weeks

2 mg mometasone or placebo

Budesonide

Isotonic saline PostESS 3months

Budesonide 0.12

Budesonide 6weeks

Typeof

Corticosteroid,

Dose, Duration of Treatment

12 months (1 year)

routine care (n = 30)

Saline/Placebo irrigations (n = 37)

Routine care (n = 30)

Tait 1078 2018 1 RCT Corticosteroid irrigation (n = 37)

Corticosteroid Irrigation Huang 1586 2019 1 RCT Corticosteroid irrigation (n = 30) Saline irrigations (n = 30)

Rawal 1588 2015 1 RCT Corticosteroid irrigation (n = 25)

Saline irrigations (n = 25)

Placebo spray (n = 21)

Placebo Irrigation and corticosteroid spray (n = 23)

Irrigation and

irrigation plus

Harvey 1077 2018 1 RCT Corticosteroid

Chaudhary 1587 2017 1 RCT (AFRS) Corticosteroid

TABLE X-19 Evidence for CRSwNP management with topical corticosteroids (non-standard delivery) Study Year LOE Study Design Study Groups