xRead - Nasal Obstruction (September 2024) Full Articles

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496

International consensus statement on rhinosinusitis

(Continues)

Fluticasone better than placebo.

4 week symptom and 16 week NP score

Fluticasone better than placebo.

4 week symptom and 16 week NP score and NPIF.

Delivery Method of Corticosteroid Clinical Endpoint Conclusions Corticosteroid via nasal irrigation Symptoms QoL Endoscopic Score Low quality evidence for additional benefit. Corticosteroid via exhalation delivery system Fluticasone better than placebo. NP symptoms SNOT22 MOS Sleep-R SF36 PGIC RSDI NPscore

Corticosteroid better than placebo.

facial pain/pressure, rhinorrhea, and

congestion/ obstruction NPscore NPIF

Nasal congestion NPscore

Anosmia/hyposmia,

NPscore Smell

QoL

Radiologic Score

exhalation delivery system

exhalation delivery system

Fine-particle inhaled corticosteroid (ICS)

exhalation through the nose (ETN)

Corticosteroid via

Corticosteroid via

twice daily (BID) for 24weeks Fluticasone 93 μ g, 186 μ g, 372 μ g

372 μ g

372 μ g

Fluticasone 93 μ g, 186 μ g,

Fluticasone 93 μ g, 186 μ g,

twice daily (BID) for 24weeks HFA-134a

twice daily (BID) for 24weeks

doses, durations,

frequencies, and surgical states

beclomethasone dipropionate

Typeof

Corticosteroid,

Dose, Duration of Treatment

Varying volumes,

Kobayashi 1592 2018 1 RCT Exhaled corticosteroid (n = 11) Placebo (n = 12)

(exhalation delivery) x3dose placebo (n = 323)

(exhalation delivery) x3dose placebo (n = 323)

Exhalation Driven Delivery Sindwani 1591 2019 1 RCT Corticosteroid (exhalation delivery) x3dose placebo (n = 323)

Corticosteroid irrigation

Leopold 1593 2019 1 RCT Corticosteroid

Soteres 1594,1603 2017 1 RCT Corticosteroid

Saline irrigations

Study Year LOE Study Design Study Groups Yoon 1589 2018 3 Meta-analysis of controlled studies

TABLE X-19 (Continued)