xRead - Nasal Obstruction (September 2024) Full Articles

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497

Orlandi et al.

Delivery Method of Corticosteroid Clinical Endpoint Conclusions Atomized solution v spray Glasgow Health Status Inventory (GHSI) Endoscopic Score Aerosol mix did better on GHSI. Endoscopic scores similar. Symptoms

Atomizer and drop were better than INCS, but

similar to drops, post

ESS in SNOT-22 and endoscopic score.

Less recurrence in the corticosteroid

nebulization group.

symptoms but similar. No evidence of HPA suppression.

between oral steroid and intrapolyp

injection. No observe

systemic effects from injection group.

Both improved

Similar outcomes

Endoscopic scores

Radiologic scores

SNOT22

ACTH stimulation Cortisol levels

Symptoms

Endoscopic score Radiology score

Cortisol and ACTH

atomizer (cf drops and spray)

nasal nebulization

Corticosteroid via nasal irrigation

intrapolyp injection vs oral

nebulization (n = 15) INCS (n = 15) Budesonide Corticosteroid via

Corticosteroid via

Corticosteroid as

Injected triamcinolone (40 mg) weekly x5 Then both groups: Fluticasone 400 μ g

(200 μ g/daily) and

Fluticasone spray (100 μ g)

150 mL saline

Aerosol (essential oils, saline,

glucocorticoids, and antibiotics)

Budesonide atomizer (0.5mg)

Budesonide drops (0.5mg)

1 mg budesonide twice daily either in atomizer of saline irrigation

Prednisone (1 mg/kg/d tapering over 2 weeks)

drops twice daily for 12weeks

Mometasone

Twice daily 6 months

Typeof

Corticosteroid,

Dose, Duration of Treatment

Study Year LOE Study Design Study Groups Atomization/Nebulization Velepic 1595 2019 1 RCT INCS + saline irrigation Aerosol (combination) Dai 1596 2017 1 RCT Corticosteroid

Kris 1604 2016 1 RCT Oral corticosteroid and Corticosteroid drops (n = 45) Intra-polyp

Corticosteroid drops (n = 45)

Corticosteroid atomization

Thamboo 1086 2014 1 RCT Corticosteroid atomization

Corticosteroid Irrigation

corticosteroid and

Neubauer 1597 2016 1 RCT INCS

Corticosteroid drops

TABLE X-19 (Continued)

Local injection