xRead - Nasal Obstruction (September 2024) Full Articles

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522

International consensus statement on rhinosinusitis

Clinical success after 1 year with 100 mg; correlation between clinical symptoms and invitro monitoring

(Continues)

Though desensitization has been proven

successful, the topical

nasal application is still under debate

Desensitization improved SNOT-22 and revision surgery rates

Desensitization improved symptoms in 73%, adverse events in 26% (no severe adverse events)

Aspirin desensitization has been proven efficacious and safe in AERD

Desensitization improved all outcomes

Study Year LOE Study Design Study Groups Clinical Endpoint Conclusions

desensitization and in vitro monitoring after 1 year

Evidence for the use of intranasal desensitization

SNOT-22, need for revision ESS

Sense of smell or taste, upper respiratory symptoms, lower respiratory

symptoms, adverse events

and IV application of aspirin for desensitization.

Effectiveness of low-dose

SNOT-22, smell score, endoscopic polyp grade

Oral, nasal, bronchial

Medication score

maintenance dose of 325 mg or 650 mg BID(n = 111)

desensitization with maintenance dose 650 mg BID after ESS (n = 34)

mg BID after ESS for NP (n = 30)

desensitization with

Patients with AERD undergoing topical

nasal lysine aspirin desensitization

undergoing different regimens of desensitization

undergoing low dose

desensitization after surgery

desensitization with

maintenance dose of 650/325 mg or 325

Patients undergoing

Ibrahim 1677 2014 4 Cohort study Patients undergoing

Patients with AERD

Patients with AERD

Patients undergoing

Parikh 1688 2014 3 Outcome research for intranasal lysine aspirin

desensitization

Adappa 1675 2018 4 Retrospective cohort study

Klimek 1687 2014 3 Outcome research for aspirin desensitization

Gosepath 1669 2001 3 Prospective cohort study

Cho 1676 2014 4 Retrospective cohort study

TABLE X-29 (Continued)