xRead - Nasal Obstruction (September 2024) Full Articles

20426984, 2021, 3, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/alr.22741 by Stanford University, Wiley Online Library on [01/07/2024]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License

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Orlandi et al.

clinically effective and can be monitored invitro

(Continues)

Desensitization improved smell score, nasal

symptom score, and oral corticosteroid use

Low dose is effective in reducing polyp

recurrence, less effective for asthma control

Long term low dose desensitization is

Desensitization improved smell score, nasal

symptom score, polyp grade

Revision rates significantly higher in AERD

nasal symptom score, reduction in oral

corticosteroid use

Surgery is less effective long term in patients withAERD

Study Year LOE Study Design Study Groups Clinical Endpoint Conclusions

Improved smell score,

symptom score, oral corticosteroid use

Polyp recurrence, symptom and

medication scores, asthma control

Recurrence of NPs and need for surgical revisions

Smell score, nasal symptom score,

endoscopic polyp grade

Recurrence (measured by Kaplan Meier curves)

symptom score, oral corticosteroid use

Number of surgical interventions

Smell score, nasal

Smell score, nasal

Clinical effect of ESS Recurrent CRS

maintenance dose of 500 mg daily after ESS for NP (n = 146)

Patients undergoing ESS for NP (n = 549)

maintenance dose of 300 mg daily (n = 40)

desensitization with

undergoing low dose

desensitization with 100 vs 300 mg

maintenance dose

Gosepath 1517 2002 4 Long term cohort study Patients with AERD undergoing long term low dose desensitization

desensitization with

AERD undergoing

desensitization with maintenance dose 650mgBID

Amar 1531 2000 4 Case control study AERD

Patients with AERD

Comert 1679 2013 4 Cohort study Patients undergoing

Patients undergoing

172 patients with

CRS w/wo asthma

Rozsasi 1674 2008 4 Comparative cohort study

Havel 1678 2013 4 Retrospective cohort study

Mendelsohn 1530 2011 4 Large retrospective cohort study

Berges-Gimeno 1680 2003 4 Large, long-term cohort study

TABLE X-29 (Continued)