xRead - Nasal Obstruction (September 2024) Full Articles

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TABLE X-30 Evidence for pathophysiology differences between CRSwNP and AFRS Study Year LOE Study Design Study Groups Clinical Endpoint Conclusions Clinical Description Promsopa 1708 2016 2 Cross-sectional prevalence study CRSwNP CRSsNP AFRS Diagnosis of asthma Significantly higher prevalence of asthma in CRSwNP (48.3%) as compared to AFRS (23.6%) and CRSsNP (16.5%). Han 1716 2013 2 Cross-sectional study AERD AFRS Asthmatic RS with allergy Asthmatic RS without allergy Nonasthmatic RS with allergy Nonasthmatic RS without allergy CF Clinical data IHC of sinonasal mucosa AFRS pathophysiology involves fungal-specific allergic reaction whereas AScA is a more undifferentiated allergic response. IL-5 is important in pathogenesis of AFRS, unlike other subclasses of eosinophilic RS. Rowan 1706 2019 4 Retrospective case series AFRS (n = 70) CRSwNP (n = 70) CRSsNP (n = 70)

Marfani 1707 2010 4 Retrospective case series AFRS (n = 47) Clinical data The majority of AFRS patients with skull base erosion were young, male, and of low socioeconomic status.

Unilateral disease present in over 59% of patients.

Clinical data Concha bullosa more prevalent in AFRS than CRSwNP. Clinical and

Prevalence of AFRS among Iranian patients with CRSwNP was 9.45%.

Patients s/p ESS for inflammatory disease AFRS (n = 27) Non-AFRS (n = 158) Clinical data AFRS were 12.6 times more likely to have bony erosion than other CRS.

Bony erosion was more common in males and African American patients.

histopathological data

Patients with > 1 year

history of CRSwNP

Bakhshaee 1717 2013 4 Prospective cohort study

Ghegan 1704 2006 4 Retrospective case series