xRead - Nasal Obstruction (September 2024) Full Articles

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528

International consensus statement on rhinosinusitis

(Continues)

AFRS, nonallergic eosinophilic fungal RS and CRSsNP patients have elevated local mast cells, eosinophils and IgE + cell numbers compared to controls.

No significant difference in eosinophils, mast cells or IgE + cell numbers between

AFRS and nonallergic

eosinophilic fungal RS, suggesting local IgE

production in all CRS subsets.

activity relative to Treg in AFRS vs controls.

T cell memory for fungal antigen was specific to fungi cultured from sinus cavities and noted in only patients with Type 2 immune response.

Serum and local total IgE were significantly increased in AFRS compared to other

groups. Local total IgE was

increased in both CRSwNP and AFRS. Local IgE

correlated with local ECP in

all subjects, and more so with fungal-specific IgEs.

Study Year LOE Study Design Study Groups Clinical Endpoint Conclusions Carney 1727 2006 4 Prospective case control study Control group AFRS Nonallergic

Increase in Th17 cells and

quantitative RT-PCR

IHC of infundibular mucosa

cytometry, Elispot and ELISA

Flow cytometry,

Fungal culture, Flow

IHC of sinonasal mucosa Serum and local IgE

eosinophilic fungal RS (NPs and

positive fungal

culture or stain, but without fungal allergy) CRSsNP

AFRS

Non-atopic controls AFRS CRSwNP Control

AFRS

CRSsNP

CRSwNP

Controls

Rai 1728 2018 4 Prospective case control study

Systemic Immunologic Response Porter 622 2014 4 Prospective case control study

Matsuwaki 1443 2013 4 Prospective case control study

TABLE X-30 (Continued)