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tors Genistein, VRT-532, and UCCF-152 in primary sinonasal epithelial cultures. JAMA Otolaryngol Head Neck Surg . 2013;139(8):822-827. 921. Zhang S, Smith N, Schuster D, et al. Quercetin increases cys tic fibrosis transmembrane conductance regulator-mediated chloride transport and ciliary beat frequency: therapeutic implications for chronic rhinosinusitis. Am J Rhinol Allergy . 2011;25(5):307-312. 922. Virgin F, Zhang S, Schuster D, et al. The bioflavonoid com pound, sinupret, stimulates transepithelial chloride transport in vitro and in vivo. Laryngoscope . 2010;120(5):1051-1056. 923. Azbell C, Zhang S, Skinner D, Fortenberry J, Sorscher EJ, Woodworth BA. Hesperidin stimulates cystic fibrosis trans membrane conductance regulator-mediated chloride secre tion and ciliary beat frequency in sinonasal epithelium. Oto laryngol Head Neck Surg . 2010;143(3):397-404. 924. Lim DJ, McCormick J, Skinner D, et al. Controlled delivery of ciprofloxacin and ivacaftor via sinus stent in a preclinical model of Pseudomonas sinusitis. Int Forum Allergy Rhinol . 2020;10(4):481-488. 925. Cho DY, Lim DJ, Mackey C, et al. Preclinical therapeutic effi cacy of the ciprofloxacin-eluting sinus stent for Pseudomonas aeruginosa sinusitis. Int Forum Allergy Rhinol . 2018;8(4):482 489. 926. Yarmohammadi H, Estrella L, Doucette J, Cunningham Rundles C. Recognizing primary immune deficiency in clin ical practice. Clin Vaccine Immunol . 2006;13(3):329-332. 927. Yel L, Ramanuja S, Gupta S. Clinical and immunologi cal features in IgM deficiency. Int Arch Allergy Immunol . 2009;150(3):291-298. 928. Bondioni MP, Duse M, Plebani A, et al. Pulmonary and sinusal changes in 45 patients with primary immunodeficien cies: computed tomography evaluation. J Comp Assist Tomogr . 2007;31(4):620-628. 929. Manning S WR, Leach J, Truelson J. Chronic sinusitis as a manifestation of primary immunodeficiency in adults. AmJ Rhinol . 1994;8(1):29-35. 930. Pimenta F, Palma SMU, Constantino-Silva RN, Grumach AS. Hypogammaglobulinemia: a diagnosis that must not be over looked. Braz J Med Biol Res . 2019;52(10):e8926. 931. Walsh JE, Gurrola JG, 2nd, Graham SM, Mott SL, Ballas ZK. Immunoglobulin replacement therapy reduces chronic rhi nosinusitis in patients with antibody deficiency. Int Forum Allergy Rhinol . 2017;7(1):30-36. 932. Watts WJ, Watts MB, Dai W, Cassidy JT, Grum CM, Weg JG. Respiratory dysfunction in patients with common variable hypogammaglobulinemia. Am Rev Respir Dis . 1986;134(4):699 703. 933. Armenaka M, Grizzanti J, Rosenstreich DL. Serum immunoglobulins and IgG subclass levels in adults with chronic sinusitis: evidence for decreased IgG3 levels. Ann Allergy . 1994;72(6):507-514. 934. Levin TA, Ownby DR, Smith PH, et al. Relationship between extremely low total serum IgE levels and rhinosinusitis. Ann Allergy Asthma Immunol. 2006;97(5):650-652. 935. Magen E, Schlesinger M, David M, Ben-Zion I, Vardy D. Selec tive IgE deficiency, immune dysregulation, and autoimmu nity. Allergy Asthma Proc . 2014;35(2):e27-33.

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