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phisms with chronic rhinosinusitis. Am J Rhinol Allergy . 2009;23(4):377-384. 986. Kim SH, Park HS, Holloway JW, Shin HD, Park CS. Associa tion between a TGFbeta1 promoter polymorphism and rhinos inusitis in aspirin-intolerant asthmatic patients. Respir Med . 2007;101(3):490-495. 987. Batikhan H, Gokcan MK, Beder E, Akar N, Ozturk A, Gerceker M. Association of the tumor necrosis factor-alpha - 308 G/A polymorphism with nasal polyposis. Eur Arch Otorhi nolaryngol . 2010;267(6):903-908. 988. Pasaje CF, Bae JS, Park BL, et al. DCBLD2 gene variations cor relate with nasal polyposis in Korean asthma patients. Lung . 2012;190(2):199-207. 989. Pasaje CF, Bae JS, Park BL, et al. Lack of association between CD58 genetic variations and aspirin-exacerbated respiratory disease in a Korean population. JAsthma . 2011;48(6):539-545. 990. Alromaih S, Mfuna-Endam L, Bosse Y, Filali-Mouhim A, Desrosiers M. CD8A gene polymorphisms predict severity factors in chronic rhinosinusitis. Int Forum Allergy Rhinol . 2013;3(8):605-611. 991. Bae JS, Pasaje CF, Park BL, et al. Genetic association analy sis of CIITA variations with nasal polyp pathogenesis in asth matic patients. MolMedRep . 2013;7(3):927-934. 992. Sitarek P, Zielinska-Blizniewska H, Dziki L, et al. Associa tion of the -14C/G MET and the -765G/C COX-2 gene poly morphisms with the risk of chronic rhinosinusitis with nasal polyps in a Polish population. DNA Cell Biol . 2012;31(7):1258 1266. 993. Schubert MS, Hutcheson PS, Graff RJ, Santiago L, Slavin RG. HLA-DQB1 *03 in allergic fungal sinusitis and other chronic hypertrophic rhinosinusitis disorders. J Allergy Clin Immunol . 2004;114(6):1376-1383. 994. Bohman A, Juodakis J, Oscarsson M, Bacelis J, Bende M, Torinsson Naluai Å. A family-based genome-wide associa tion study of chronic rhinosinusitis with nasal polyps impli cates several genes in the disease pathogenesis. PLoS One . 2017;12(12):e0185244. 995. Cheng YK, Lin CD, Chang WC, et al. Increased prevalence of interleukin-1 receptor antagonist gene polymorphism in patients with chronic rhinosinusitis. Arch Otolaryngol Head NeckSurg . 2006;132(3):285-290. 996. Zielinska-Blizniewska H, Sitarek P, Milonski J, et al. Asso ciation of the -33C/G OSF-2 and the 140A/G LF gene poly morphisms with the risk of chronic rhinosinusitis with nasal polyps in a Polish population. Mol Biol Rep . 2012;39(5):5449 5457. 997. Kilty SJ, Bosse Y, Cormier C, Endam LM, Desrosiers MY. Poly morphisms in the SERPINA1 (Alpha-1-Antitrypsin) gene are associated with severe chronic rhinosinusitis unresponsive to medical therapy. Am J Rhinol Allergy . 2010;24(1):e4-e9. 998. Cormier C, Bosse Y, Mfuna L, Hudson TJ, Desrosiers M. Poly morphisms in the tumour necrosis factor alpha-induced pro tein 3 (TNFAIP3) gene are associated with chronic rhinosi nusitis. J Otolaryngol Head Neck Surg . 2009;38(1):133-141. 999. Tournas A, Mfuna L, Bosse Y, Filali-Mouhim A, Grenier JP, Desrosiers M. A pooling-based genome-wide association study implicates the p73 gene in chronic rhinosinusitis. JOto laryngol Head Neck Surg . 2010;39(2):188-195.