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International consensus statement on rhinosinusitis

controlled trial of intranasal fluconazole. EXCLI J . 2016;15:95 102. 1163. Ponikau JU, Sherris DA, Weaver A, Kita H. Treatment of chronic rhinosinusitis with intranasal amphotericin B: a ran domized, placebo-controlled, double-blind pilot trial. JAllergy Clin Immunol . 2005;115(1):125-131. 1164. Liang KL, Su MC, Shiao JY, et al. Amphotericin B irrigation for the treatment of chronic rhinosinusitis without nasal polyps: a randomized, placebo-controlled, double-blind study. Am J Rhinol . 2008;22(1):52-58. 1165. Corradini C, Del Ninno M, Buonomo A, et al. Amphotericin B and lysine acetylsalicylate in the combined treatment of nasal polyposis associated with mycotic infection. J Investig Allergol Clin Immunol . 2006;16(3):188-193. 1166. Shin SH, Ye MK. Effects of topical amphotericin B on expression of cytokines in nasal polyps. Acta Otolaryngol . 2004;124(10):1174-1177. 1167. Weschta M, Rimek D, Formanek M, Polzehl D, Podbielski A, Riechelmann H. Topical antifungal treatment of chronic rhinosinusitis with nasal polyps: a randomized, double-blind clinical trial. J Allergy Clin Immunol . 2004;113(6):1122-1128. 1168. Zia S, Naqvi SU, Ahmed S, Farrukh MS, Sheikh SM. Role of Amphotericin B in Nasal Irrigation for Chronic Rhinosinusitis with Nasal Polyps. J Coll Physicians Surg Pak . 2019;29(8):732 735. 1169. Gerlinger I, Fittler A, Mayer A, et al. Postoperative application of amphotericin B nasal spray in chronic rhinosinusitis with nasal polyposis. Can recidive polyposis be prevented? Orvosi hetilap . 2008;149:1737-1746. 1170. Yousefi J, Akhavan A, Hoseini-Motlagh R, Banaei-Boroujeni S, Panahi Y, Khosravi MH. Effect of amphotericin B on treat ment of chronic rhinosinusitis: a double-blind randomized clinical trial. Razavi Int. J. Med . 2017;5(4):e64550. 1171. Jiang RS, Twu CW, Liang KL. Efficacy of nasal irrigation with 200 μ g/mL amphotericin B after functional endoscopic sinus surgery: a randomized, placebo-controlled, double-blind study. Int Forum Allergy Rhinol . 2018;8(1):41-48. 1172. Ebbens FA, Scadding GK, Badia L, et al. Amphotericin B nasal lavages: not a solution for patients with chronic rhinosinusitis. J Allergy Clin Immunol . 2006;118(5):1149-1156. 1173. Hopkins C, Hettige R, Soni-Jaiswal A, et al. CHronic Rhinos inusitis Outcome MEasures (CHROME), developing a core outcome set for trials of interventions in chronic rhinosinusi tis. Rhinology . 2018;56(1):22-32. 1174. Pinto JM, Mehta N, DiTineo M, Wang J, Baroody FM, Naclerio RM. A randomized, double-blind, placebo-controlled trial of anti-IgE for chronic rhinosinusitis. Rhinology . 2010;48(3):318 324. 1175. Ho J, Hamizan AW, Alvarado R, Rimmer J, Sewell WA, Harvey RJ. Systemic predictors of eosinophilic chronic rhinosinusitis. Am J Rhinol Allergy . 2018;32(4):252-257. 1176. Lal D, Hopkins C, Divekar RD. SNOT-22-based clusters in chronic rhinosinusitis without nasal polyposis exhibit distinct endotypic and prognostic differences. Int Forum Allergy Rhi nol . 2018;8(7):797-805. 1177. Wilson AM, White PS, Gardiner Q, Nassif R, Lipworth BJ. Effects of leukotriene receptor antagonist therapy in patients with chronic rhinosinusitis in a real life rhinology clinic set ting. Rhinology . 2001;39(3):142-146.

chronic rhinosinusitis. JAMA Otolaryngol Head Neck Surg . 2016;142(2):138-142. 1146. Scheinberg PA, Otsuji A. Nebulized antibiotics for the treat ment of acute exacerbations of chronic rhinosinusitis. Ear Nose Throat J . 2002;81(9):648-652. 1147. Kamijyo A, Matsuzaki Z, Kikushima K, et al. Fosfomycin nebulizer therapy to chronic sinusitis. Auris Nasus Larynx . 2001;28(3):227-232. 1148. Vaughan WC, Carvalho G. Use of nebulized antibiotics for acute infections in chronic sinusitis. Otolaryngol Head Neck Surg . 2002;127(6):558-568. 1149. Leonard DW, Bolger WE. Topical antibiotic therapy for recal citrant sinusitis. Laryngoscope . 1999;109(4):668-670. 1150. Mainz JG, Schädlich K, Schien C, et al. Sinonasal inhalation of tobramycin vibrating aerosol in cystic fibrosis patients with upper airway Pseudomonas aeruginosa colonization: results of a randomized, double-blind, placebo-controlled pilot study. Drug Des Devel Ther . 2014;8:209. 1151. Ezzat W, Fawaz S, Rabie H, Hamdy T, Shokry Y. Effect of topical ofloxacin on bacterial biofilms in refractory post sinus surgery rhino-sinusitis. Eur Arch Otorhinolaryngol . 2015;272(9):2355-2361. 1152. Di Cicco M, Alicandro G, Claut L, et al. Efficacy and tolerabil ity of a new nasal spray formulation containing hyaluronate and tobramycin in cystic fibrosis patients with bacterial rhi nosinusitis. J Cyst Fibros . 2014;13(4):455-460. 1153. Lee VS, Davis GE. Culture-directed topical antibiotic treatment for chronic rhinosinusitis. Am J Rhinol Allergy . 2016;30(6):414-417. 1154. Maniakas A, Desrosiers M. Azithromycin add-on therapy in high-risk postendoscopic sinus surgery patients failing cor ticosteroid irrigations: a clinical practice audit. Am J Rhinol Allergy . 2014;28(2):151-155. 1155. Lee JT, Chiu AG. Topical anti-infective sinonasal irriga tions: update and literature review. Am J Rhinol Allergy . 2014;28(1):29-38. 1156. Woodhouse BM, Cleveland KW. Nebulized antibiotics for the treatment of refractory bacterial chronic rhinosinusitis. Ann Pharmacother . 2011;45(6):798-802. 1157. Huang A, Govindaraj S. Topical therapy in the management of chronic rhinosinusitis. Curr Opin Otolaryngol Head Neck Surg . 2013;21(1):31-38. 1158. Wei JL, Sykes KJ, Johnson P, He J, Mayo MS. Safety and effi cacy of once-daily nasal irrigation for the treatment of pedi atric chronic rhinosinusitis. Laryngoscope . 2011;121(9):1989 2000. 1159. Ebbens FA, Georgalas C, Rinia AB, van Drunen CM, Lund VJ, Fokkens WJ. The fungal debate: where do we stand today? Rhi nology . 2007;45(3):178-189. 1160. Kennedy DW, Kuhn FA, Hamilos DL, et al. Treatment of chronic rhinosinusitis with high-dose oral terbinafine: a double blind, placebo-controlled study. Laryngoscope . 2005;115(10):1793-1799. 1161. Amodu EJ, Fasunla AJ, Akano AO, Daud Olusesi A. Chronic rhinosinusitis: correlation of symptoms with com puted tomography scan findings. Pan Afr Med J . 2014;18:40. 1162. Hashemian F, Hashemian F, Molaali N, Rouini M, Roohi E, Torabian S. Clinical effects of topical antifungal therapy in chronic rhinosinusitis: a randomized, double-blind, placebo