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terial biofilms in chronic rhinosinusitis; distribution and prevalence. Acta Otolaryngol . 2016;136(1):109-112. 1402. Wang X, Du J, Zhao C. Bacterial biofilms are associated with inflammatory cells infiltration and the innate immunity in chronic rhinosinusitis with or without nasal polyps. Inflam mation . 2014;37(3):871-879. 1403. Arjomandi H, Gilde J, Zhu S, et al. Relationship of eosinophils and plasma cells to biofilm in chronic rhinosinusitis. AmJRhi nol Allergy . 2013;27(4):e85-e90. 1404. Prince AA, Steiger JD, Khalid AN, et al. Prevalence of biofilm forming bacteria in chronic rhinosinusitis. Am J Rhinol . 2008;22(3):239-245. 1405. Barham HP, Cooper SE, Anderson CB, et al. Solitary chemosensory cells and bitter taste receptor signaling in human sinonasal mucosa. Int Forum Allergy Rhinol . 2013;3(6):450-457. 1406. Tizzano M, Cristofoletti M, Sbarbati A, Finger TE. Expression of taste receptors in solitary chemosensory cells of rodent air ways. BMC Pulm Med . 2011;11:3. 1407. Lee RJ, Kofonow JM, Rosen PL, et al. Bitter and sweet taste receptors regulate human upper respiratory innate immunity. J Clin Invest . 2014;124(3):1393-1405. 1408. Howitt MR, Lavoie S, Michaud M, et al. Tuft cells, taste chemosensory cells, orchestrate parasite type 2 immunity in thegut. Science . 2016;351(6279):1329-1333. 1409. Kohanski MA, Workman AD, Patel NN, et al. Solitary chemosensory cells are a primary epithelial source of IL-25 in patients with chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol . 2018;142(2):460-469.e467. 1410. von Moltke J, Ji M, Liang HE, Locksley RM. Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit. Nature . 2016;529(7585):221-225. 1411. Chen F, Hong H, Sun Y, et al. Nasal interleukin 25 as a novel biomarker for patients with chronic rhinosinusitis with nasal polyps and airway hypersensitiveness: a pilot study. Ann Allergy Asthma Immunol . 2017;119(4):310-316.e312. 1412. Iinuma T, Okamoto Y, Yamamoto H, et al. Interleukin-25 and mucosal T cells in noneosinophilic and eosinophilic chronic rhinosinusitis. Ann Allergy Asthma Immunol . 2015;114(4):289 298. 1413. Lam M, Hull L, Imrie A, et al. Interleukin-25 and interleukin 33 as mediators of eosinophilic inflammation in chronic rhi nosinusitis. Am J Rhinol Allergy . 2015;29(3):175-181. 1414. Ualiyeva S, Hallen N, Kanaoka Y, et al. Airway brush cells gen erate cysteinyl leukotrienes through the ATP sensor P2Y2. Sci Immunol . 2020;5(43):eaax7224. 1415. Schlosser RJ, Soler ZM, Schmedes GW, Storck K, Mulligan JK. Impact of vitamin D deficiency upon clinical presentation in nasal polyposis. Int Forum Allergy Rhinol . 2014;4(3):196-199. 1416. Ozkara S, Keles E, Ilhan N, Gungor H, Kaygusuz I, Alpay HC. The relationship between Th1/Th2 balance and 1alpha,25 dihydroxyvitamin D(3) in patients with nasal polyposis. Eur Arch Otorhinolaryngol . 2012;269(12):2519-2524. 1417. Carroll WW, Schlosser RJ, O’Connell BP, Soler ZM, Mulligan JK. Vitamin D deficiency is associated with increased human sinonasal fibroblast proliferation in chronic rhinosinusitis with nasal polyps. Int Forum Allergy Rhinol . 2016;6(6):605-10. 1418. Rostkowska-Nadolska BLM, Gawron W, Kutner A, Bochnia M. The influence of calcitriol and tacalcitol on proliferation

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