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International consensus statement on rhinosinusitis

and toxic shock syndrome toxin 1 in nasal polyps. AmJRhinol Allergy . 2011;25(1):19-24. 1434. Van Zele T, Vaneechoutte M, Holtappels G, Gevaert P, van Cauwenberge P, Bachert C. Detection of enterotoxin DNA in Staphylococcus aureus strains obtained from the middle meatus in controls and nasal polyp patients. Am J Rhinol . 2008;22(3):223-227. 1435. Chen J-B, James LK, Davies AM, et al. Antibodies and super antibodies in patients with chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol . 2017;139(4):1195-1204.e1111. 1436. Patou J, Gevaert P, Van Zele T, Holtappels G, van Cauwen berge P, Bachert C. Staphylococcus aureus enterotoxin B, pro tein A, and lipoteichoic acid stimulations in nasal polyps. J Allergy Clin Immunol . 2008;121(1):110-115. 1437. Li Z, Levast B, Madrenas J. Staphylococcus aureus downreg ulates IP-10 production and prevents Th1 cell recruitment. J Immunol . 2017;198(5):1865-1874. 1438. Perez-Novo CA, Waeytens A, Claeys C, Cauwenberge PV, Bachert C. Staphylococcus aureus enterotoxin B regulates prostaglandin E2 synthesis, growth, and migration in nasal tis sue fibroblasts. J Infect Dis . 2008;197(7):1036-1043. 1439. Huvenne W, Callebaut I, Reekmans K, et al. Staphylococ cus aureus enterotoxin B augments granulocyte migration and survival via airway epithelial cell activation. Allergy . 2010;65(8):1013-1020. 1440. Van Zele T, Gevaert P, Holtappels G, van Cauwenberge P, Bachert C. Local immunoglobulin production in nasal polyposis is modulated by superantigens. Clin Exp Allergy . 2007;37(12):1840-1847. 1441. Gevaert P, Nouri-Aria KT, Wu H, et al. Local receptor revision and class switching to IgE in chronic rhinosinusitis with nasal polyps. Allergy . 2013;68(1):55-63. 1442. Zhang N, Holtappels G, Gevaert P, et al. Mucosal tissue poly clonal IgE is functional in response to allergen and SEB. Allergy . 2011;66(1):141-148. 1443. Matsuwaki Y, Uno K, Okushi T, Otori N, Moriyama H. Total and antigen- (fungi, mites and staphylococcal enterotoxins) specific IgEs in nasal polyps is related to local eosinophilic inflammation. Int Arch Allergy Immunol . 2013;161(Suppl 2):147-153. 1444. Shamji MH, Thomsen I, Layhadi JA, et al. Broad IgG repertoire in patients with chronic rhinosinusitis with nasal polyps regulates proinflammatory IgE responses. J Allergy Clin Immunol . 2019;143(6):2086-2094.e2082. 1445. Ou J, Wang J, Xu Y, et al. Staphylococcus aureus superantigens are associated with chronic rhinosinusitis with nasal polyps: a meta-analysis. Eur Arch Otorhinolaryngol . 2014;271(10):2729 2736. 1446. Stentzel S, Teufelberger A, Nordengrün M, et al. Staphylo coccal serine protease–like proteins are pacemakers of aller gic airway reactions to Staphylococcus aureus. J Allergy Clin Immunol . 2017;139(2):492-500.e498. 1447. Teufelberger AR, Nordengrün M, Braun H, et al. The IL 33/ST2 axis is crucial in type 2 airway responses induced by Staphylococcus aureus–derived serine protease–like protein D. J Allergy Clin Immunol . 2018;141(2):549-559.e547. 1448. Lan F, Zhang N, Holtappels G, et al. Staphylococcus aureus induces a mucosal type 2 immune response via epithelial cell–

of fibroblasts cultured from nasal polyps. Adv Clin Exp Med . 2007;16(2):213-219. 1419. Rostkowska-Nadolska B, Sliupkas-Dyrda E, Potyka J, et al. Vitamin D derivatives: calcitriol and tacalcitol inhibits interleukin-6 and interleukin-8 expression in human nasal polyp fibroblast cultures. AdvMedSci . 2010;55(1):86-92. 1420. Fraczek M, Rostkowska-Nadolska B, Kusmierz D, et al. Vita min D analogs decrease in vitro secretion of RANTES and enhance the effect of budesonide. AdvMedSci . 2012;57(2):290 295. 1421. Wang L-F, Tai C-F, Chien C-Y, Chiang F-Y, Chen JY-F. Vita min D decreases the secretion of matrix metalloproteinase 2 and matrix metalloproteinase-9 in fibroblasts derived from Taiwanese patients with chronic rhinosinusitis with nasal polyposis. Kaohsiung J Med Sci . 2015;31(5):235-240. 1422. Wang L-F, Chien C-Y, Tai C-F, Chiang F-Y, Chen JY-F. Vita min D decreases the secretion of eotaxin and RANTES in nasal polyp fibroblasts derived from Taiwanese patients with chronic rhinosinusitis with nasal polyps. Kaohsiung J Med Sci . 2015;31(2):63-69. 1423. Fraczek M. R-NB, Sliupkas-Dyrda E., Kusmierz D., Pniak J., Latocha M. The influence of vitamin D derivatives on the expression of apoptotic genes in nasal polyp fibroblasts. Adv Clin Exp Med . 2010;19(6):679-684. 1424. Rostkowska-Nadolska B, Fraczek M, Gawron W, Latocha M. Influence of vitamin D(3) analogues in combination with budesonid R on proliferation of nasal polyp fibroblasts. Acta Biochim Pol . 2009;56(2):235-242. 1425. Van Zele T, Gevaert P, Watelet JB, et al. Staphylococcus aureus colonization and IgE antibody formation to enterotox ins is increased in nasal polyposis. J Allergy Clin Immunol . 2004;114(4):981-983. 1426. Corriveau M-N, Zhang N, Holtappels G, Van Roy N, Bachert C. Detection of Staphylococcus aureus in nasal tissue with pep tide nucleic acid–fluorescence in situ hybridization. AmJRhi nol Allergy . 2009;23(5):461-465. 1427. Hayes SM, Biggs TC, Goldie SP, et al. Staphylococcus aureus internalization in mast cells in nasal polyps: characteriza tion of interactions and potential mechanisms. J Allergy Clin Immunol . 2020;145(1):147-159. 1428. Schmidt F, Meyer T, Sundaramoorthy N, et al. Characteriza tion of human and Staphylococcus aureus proteins in respira tory mucosa by in vivo-and immunoproteomics. J Proteomics . 2017;155:31-39. 1429. Tripathi A, Kern R, Conley DB, et al. Staphylococcal exotoxins and nasal polyposis: analysis of systemic and local responses. AmJRhinol . 2005;19(4):327-333. 1430. Rha MS, Kim SW, Chang DY, et al. Superantigen-related Th2 CD4 + T Cells in nonasthmatic chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol . 2020;145(5):1378 1388.e10. 1431. Conley DB, Tripathi A, Seiberling KA, et al. Superantigens and chronic rhinosinusitis II: analysis of T-cell receptor V beta domains in nasal polyps. AmJRhinol . 2006;20(4):451-455. 1432. Wang M, Shi P, Yue Z, et al. Superantigens and the expres sion of T-cell receptor repertoire in chronic rhinosinusitis with nasal polyps. Acta Otolaryngol . 2008;128(8):901-908. 1433. Kim ST, Chung SW, Jung JH, Ha JS, Kang IG. Association of T cells and eosinophils with Staphylococcus aureus exotoxin A