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with fluticasone for nasal polyposis. J Allergy Clin Immunol . 2019;143(1):126-134.e125. 1594. Soteres DF, Messina J, Carothers J, Mahmoud R, Djupes land PG. Navigate i: a randomized double-blind trial of a flu ticasone propionate exhalation delivery system (FLU-EDS) for treatment of chronic rhinosinusitis with nasal polyps (CRSWNP). J Allergy Clin Immunol . 2017;139 (2 Suppl 1):AB66. 1595. Velepic M, Manestar D, Perkovic I, Skalamera D, Braut T. Inhalation aerosol therapy in the treatment of chronic rhinos inusitis: a prospective randomized study. J Clin Pharmacol . 2019;59(12):1648-1655. 1596. Dai Q, Duan C, Liu Q, Yu H. Effect of nebulized budesonide on decreasing the recurrence of allergic fungal rhinosinusitis. Am J Otolaryngol . 2017;38(3):321-324. 1597. Neubauer PD, Schwam ZG, Manes RP. Comparison of intranasal fluticasone spray, budesonide atomizer, and budes onide respules in patients with chronic rhinosinusitis with polyposis after endoscopic sinus surgery. Int Forum Allergy Rhinol . 2016;6(3):233-237. 1598. Dawson B, Gutteridge I, Cervin A, Robinson D. The effects of nasal lavage with betamethasone cream post-endoscopic sinus surgery: clinical trial. J Laryngol Otol . 2018;132(2):143 149. 1599. Dawson B, Gutteridge I, Cervin A, Robinson D. The impact of topical betamethasone nasal irrigation on endogenous cortisol production in patients following functional endoscopic sinus surgery for chronic rhinosinusitis. Allergy: European J Allergy Clin Immunol . 2016;71 (Suppl 102):14. 1600. Cai Y, Gudis DA. Is topical high-volume budesonide sinus irri gation safe? Laryngoscope . 2018;128(4):781-782. 1601. Soudry E, Wang J, Vaezeafshar R, Katznelson L, Hwang PH. Safety analysis of long-term budesonide nasal irrigations in patients with chronic rhinosinusitis post endoscopic sinus surgery. Int Forum Allergy Rhinol . 2016;6(6):568-572. 1602. Smith KA, French G, Mechor B, Rudmik L. Safety of long-term high-volume sinonasal budesonide irrigations for chronic rhi nosinusitis. Int Forum Allergy Rhinol . 2016;6(3):228-232. 1603. Schenkel E, Messina J, Carothers J, Djupesland P, Mahmoud R. Exhalation delivery system with fluticasone (EDS-FLU) improves peak nasal inspiratory flow (PNIF) in crswnp. Ann. Allergy Asthma Immunol. 2017;119 (5 Suppl 1):S92. 1604. Kiris M, Muderris T, Yalciner G, Bercin S, Sevil E, Gul F. Intrapolyp steroid injection for nasal polyposis: randomized trial of safety and efficacy. Laryngoscope . 2016;126(8):1730-1735. 1605. Han JK, Forwith KD, Smith TL, et al. RESOLVE: a ran domized, controlled, blinded study of bioabsorbable steroid eluting sinus implants for in-office treatment of recurrent sinonasal polyposis. Int Forum Allergy Rhinol . 2014;4(11):861 870. 1606. Forwith KD, Han JK, Stolovitzky JP, et al. RESOLVE: bioab sorbable steroid-eluting sinus implants for in-office treatment of recurrent sinonasal polyposis after sinus surgery: 6-month outcomes from a randomized, controlled, blinded study. Int Forum Allergy Rhinol . 2016;6(6):573-581. 1607. Kern RC, Stolovitzky JP, Silvers SL, et al. A phase 3 trial of mometasone furoate sinus implants for chronic sinusi tis with recurrent nasal polyps. Int Forum Allergy Rhinol . 2018;8(4):471-481.

1578. Lang D, McNeill J. Double-blind controlled-study of effect of topical steroids on nasal polyps. Presented at Oto-Rhino Laryngological Research Society (ORS). Clin Otolaryngo . 1983;8:139. 1579. Fandino M, Macdonald KI, Lee J, Witterick IJ. The use of post operative topical corticosteroids in chronic rhinosinusitis with nasal polyps: a systematic review and meta-analysis. AmJRhi nol Allergy . 2013;27(5):e146-e157. 1580. Rudmik L, Schlosser RJ, Smith TL, Soler ZM. Impact of topical nasal steroid therapy on symptoms of nasal polyposis: a meta analysis. Laryngoscope . 2012;122(7):1431-1437. 1581. Ikeda K, Ito S, Hibiya R, et al. Postoperative management of eosinophilic chronic rhinosinusitis with nasal polyps: impact of high-dose corticosteroid nasal spray. Int Arch Otorhino laryngol . 2019;23(1):101-103. 1582. Venkatesan N, Lavigne P, Lavigne F, Hamid Q. Effects of flu ticasone furoate on clinical and immunological outcomes (IL 17) for patients with nasal polyposis naive to steroid treatment. Ann Otol Rhinol Laryngol . 2016;125(3):213-218. 1583. Derendorf H, Meltzer EO. Molecular and clinical pharma cology of intranasal corticosteroids: clinical and therapeutic implications. Allergy . 2008;63(10):1292-1300. 1584. Verkerk MM, Bhatia D, Rimmer J, Earls P, Sacks R, Harvey RJ. Intranasal steroids and the myth of mucosal atrophy: a system atic review of original histological assessments. AmJ Rhinol Allergy .. 2015;29(1):3-18. 1585. Do TQ, Barham HP, Earls P, et al. Clinical implications of mucosal remodeling from chronic rhinosinusitis. Int Forum Allergy Rhinol . 2016;6(8):835-840. 1586. Huang ZZ, Chen XZ, Huang JC, et al. Budesonide nasal irriga tion improved Lund-Kennedy endoscopic score of chronic rhi nosinusitis patients after endoscopic sinus surgery. Eur Arch Otorhinolaryngol . 2019;276(5):1397-1403. 1587. Chaudhary N, Gupta S, Verma RK, Choudhary SR. Budes onide nasal douching: an effective method in postoperative AFRS management. J Clin Diagn Res. 2017;11(12):MC01-MC03. 1588. Rawal RB, Deal AM, Ebert CS, Jr., et al. Post-operative budes onide irrigations for patients with polyposis: a blinded, ran domized controlled trial. Rhinology . 2015;53(3):227-234. 1589. Yoon HY, Lee HS, Kim IH, Hwang SH. Post-operative cor ticosteroid irrigation for chronic rhinosinusitis after endo scopic sinus surgery: a meta-analysis. Clin Otolaryngol . 2018;43(2):525-532. 1590. Bernstein JA, Messina JC, Sacks HJ, Djupesland PG, Mah moud RA. Evidence is limited for the efficacy and safety of cor ticosteroid irrigation in chronic rhinosinusitis (CRS). JAllergy Clin Immunol . 2019;143 (2 Suppl):AB282. 1591. Sindwani R, Han JK, Soteres DF, et al. NAVIGATE I: ran domized, placebo-controlled, double-blind trial of the exhala tion delivery system with fluticasone for chronic rhinosinusi tis with nasal polyps. Am J Rhinol Allergy . 2019;33(1):69-82. 1592. Kobayashi Y, Yasuba H, Asako M, et al. HFA-BDP metered dose inhaler exhaled through the nose improves eosinophilic chronic rhinosinusitis with bronchial asthma: a blinded, placebo-controlled study. Front Immunol . 2018;9:2192. 1593. Leopold DA, Elkayam D, Messina JC, Kosik-Gonzalez C, Djupesland PG, Mahmoud RA. NAVIGATE II: random ized, double-blind trial of the exhalation delivery system