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International consensus statement on rhinosinusitis

CRSwNP: doxycycline, methylprednisolone, mepolizumab and omalizumab. Clin Transl Allergy . 2015;5(S4):P41. 1624. Parasher AK, Kidwai SM, Konuthula N, et al. The role of doxycycline in the management of chronic rhinosinusitis with nasal polyps. Am J Otolaryngol . 2019;40(4):467-472. 1625. Bezerra T, Soter AC, Pezato R, et al. Long-term low-dose doxycycline for difficult-to-treat chronic rhinosinusitis with polyps. Otolaryngol Head Neck Surg . 2014;151(1_suppl):P121 P122. 1626. Pinto Bezerra Soter AC, Bezerra TF, Pezato R, et al. Prospec tive open-label evaluation of long-term low-dose doxycycline for difficult-to-treat chronic rhinosinusitis with nasal polyps. Rhinology . 2017;55(2):175-180. 1627. Hoza J, Salzman R, Starek I, Schalek P, Kellnerova R. Effi cacy and safety of erdosteine in the treatment of chronic rhi nosinusitis with nasal polyposis - a pilot study. Rhinology . 2013;51(4):323-327. 1628. Oakley GM, Harvey RJ, Lund VJ. The role of macrolides in chronic rhinosinusitis (CRSsNP and CRSwNP). Curr Allergy AsthmaRep . 2017;17(5):30. 1629. Hashiba M, Baba S. Efficacy of long-term administration of clarithromycin in the treatment of intractable chronic sinusi tis. Acta Otolaryngol Suppl . 1996;525:73-78. 1630. Fokkens WJ, Lund VJ, Mullol J, et al. European position paper on rhinosinusitis and nasal polyps. 2012. Rhinology Supple ment . 2012;23:3 p preceding table of contents, 1-298. 1631. Peric A, Baletic N, Milojevic M, et al. Effects of preoperative clarithromycin administration in patients with nasal polypo sis. West Indian Med J . 2014;63(7):721-727. 1632. Varvyanskaya A, Lopatin A. Efficacy of long-term low-dose macrolide therapy in preventing early recurrence of nasal polyps after endoscopic sinus surgery. Int Forum Allergy Rhi nol . 2014;4(7):533-541. 1633. Korkmaz H, Ocal B, Tatar EC, et al. Biofilms in chronic rhinos inusitis with polyps: is eradication possible? Eur Arch Otorhi nolaryngol . 2014;271(10):2695-2702. 1634. Lasso A, Masoudian P, Quinn JG, et al. Long-term low-dose macrolides for chronic rhinosinusitis in adults - a systematic review of the literature. Clin Otolaryngol . 2017;42(3):637-650. 1635. Wong AYS, Chan EW, Anand S, Worsley AJ, Wong ICK. Man aging cardiovascular risk of macrolides: systematic review and meta-analysis. DrugSaf . 2017;40(8):663-677. 1636. Watelet J-B, Demetter P, Claeys C, Van Cauwenberge P, Cuvelier C, Bachert C. Wound healing after paranasal sinus surgery: neutrophilic inflammation influences the outcome. Histopathology . 2006;48(2):174-181. 1637. Dabirmoghaddam P, Mehdizadeh Seraj J, Bastaninejad S, Meighani A, Mokhtari Z. The efficacy of clarithromycin in patients with severe nasal polyposis. Acta Med Iran . 2013;51(6):359-364. 1638. Peric A, Vojvodic D, Matkovic-Jozin S. Effect of long-term, low-dose clarithromycin on T helper 2 cytokines, eosinophilic cationic protein and the ‘regulated on activation, normal T cell expressed and secreted’ chemokine in the nasal secretions of patients with nasal polyposis. J Laryngol Otol . 2012;126(5):495 502. 1639. Haruna S, Shimada C, Ozawa M, Fukami S, Moriyama H. A study of poor responders for long-term, low-dose macrolide

1608. Stolovitzky JP, Kern RC, Han JK, et al. In-office placement of mometasone furoate sinus implants for recurrent nasal polyps: a pooled analysis. Am J Rhinol Allergy . 2019;33(5):545 558. 1609. Taulu R, Bizaki AJ, Numminen J, Rautiainen M. A prospec tive, randomized clinical study comparing drug eluting stent therapy and intranasal corticoid steroid therapy in the treat ment of patients with chronic rhinosinusitis. Rhinology . 2017;55(3):218-226. 1610. Businco LD, Mattei A, Laurino S, et al. Steroid-Eluting Eth moidal stent versus antero-posterior ethmoidectomy: compar ison of efficacy and safety in allergic patients. Otolaryngol Pol . 2016;70(2):6-12. 1611. Han JK, Marple BF, Smith TL, et al. Effect of steroid-releasing sinus implants on postoperative medical and surgical inter ventions: an efficacy meta-analysis. Int Forum Allergy Rhinol . 2012;2(4):271-279. 1612. Forwith KD, Chandra RK, Yun PT, Miller SK, Jampel HD. ADVANCE: a multisite trial of bioabsorbable steroid-eluting sinus implants. Laryngoscope . 2011;121(11):2473-2480. 1613. Head K, Chong LY, Hopkins C, Philpott C, Burton MJ, Schilder AG. Short-course oral steroids alone for chronic rhi nosinusitis. Cochrane Database Syst Rev . 2016;4:Cd011991. 1614. Head K, Chong LY, Hopkins C, Philpott C, Schilder AG, Burton MJ. Short-course oral steroids as an adjunct ther apy for chronic rhinosinusitis. Cochrane Database Syst Rev . 2016;4:Cd011992. 1615. Leung RM, Dinnie K, Smith TL. When do the risks of repeated courses of corticosteroids exceed the risks of surgery? Int Forum Allergy Rhinol . 2014;4(11):871-876. 1616. Ecevit MC, Erdag TK, Dogan E, Sutay S. Effect of steroids for nasal polyposis surgery: a placebo-controlled, randomized, double-blind study. Laryngoscope . 2015;125(9):2041-2045. 1617. Kirtsreesakul V, Wongsritrang K, Ruttanaphol S. Does oral prednisolone increase the efficacy of subsequent nasal steroids in treating nasal polyposis? Am J Rhinol Allergy . 2012;26(6):455-462. 1618. Vaidyanathan S, Barnes M, Williamson P, Hopkinson P, Don nan PT, Lipworth B. Treatment of chronic rhinosinusitis with nasal polyposis with oral steroids followed by topical steroids: a randomized trial. Ann Intern Med . 2011;154(5):293-302. 1619. Van Zele T, Gevaert P, Holtappels G, et al. Oral steroids and doxycycline: two different approaches to treat nasal polyps. J Allergy Clin Immunol . 2010;125(5):1069-1076.e1064. 1620. Benítez P, Alobid I, de Haro J, et al. A short course of oral pred nisone followed by intranasal budesonide is an effective treat ment of severe nasal polyps. Laryngoscope . 2006;116(5):770 775. 1621. Hissaria P, Smith W, Wormald PJ, et al. Short course of sys temic corticosteroids in sinonasal polyposis: a double-blind, randomized, placebo-controlled trial with evaluation of out come measures. J Allergy Clin Immunol . 2006;118(1):128-133. 1622. Sreenath SB, Taylor RJ, Miller JD, et al. A prospective ran domized cohort study evaluating 3 weeks vs 6 weeks of oral antibiotic treatment in the setting of “maximal medical ther apy” for chronic rhinosinusitis. Int Forum Allergy Rhinol . 2015;5(9):820-828. 1623. De Schryver E, Calus L, Van Zele T, Bachert C, Gevaert P. Comparison of different medical treatment options for