xRead - Olfactory Disorders (September 2023)

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INTERNATIONAL CONSENSUS ON OLFACTION

TABLE VII.12 (Continued)

Study design Study groups

Clinical end point

Topic

Study

Year LOE

Conclusions

Yuet al 658

Hippocampal volumes lower in MCI than in HCs Correlation between UPSIT R scores and volumes AD and MCI scores lower than HC scores Strong relationships found between CSIT scores and volumes of the amygdala, and the left precentral and inferior frontal gyri ApoE ε 4 allele more common in hyposmics who have lower MMSE, memory, language, visuospatial, and executive function scores No difference between groups in regional A β and tauburden Hyposmic group had smaller entorhinal cortex volumes A β -positive hyposmics had reduced volumes of global

2019 4

Case

31MCI 9HCs

UPSIT R MRI brain

control

structure volumes

Wuet al 659

2019 4

Case

37AD 27MCI 30HCs

CSIT MRI brain

control

structure volumes

Baeket al 660

2020 4

Case

55 hyposmic 72 nonhyposmic

B-SIT Cognitive tests MRI brain

control

structure volumes

cortex, superior and middle temporal, and entorhinal cortices,

amygdala, and hippocampus

Beachet al 661

2020 4

Case

66ADD 29ADD/DLB 39ADD/LBD not meeting criteria for DLB 21PDD + AD 27PDD-AD 84HCs

UPSIT R

Patients with

control

neuropathologically confirmed ADD + DLB have worse olfaction than those with ADD alone

Devanand et al 662

B-SIT and BOMCT each predicted dementia (11% converted). Only 3.4% converted to dementia if they had intact olfaction and a good score on the BOMCT

B-SIT Cognitive tests (eg, BOMCT)

2020 3

Cohort

1037

community living older adults without dementia; 749 followed up within 4-year period

(Continues)