xRead - Olfactory Disorders (September 2023)

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PATEL et al.

TABLE VII.12 (Continued)

Study design Study groups

Clinical end point

Topic

Study

Year LOE

Conclusions

Lianet al 653

Frequency of OD was 50% defined by SS-TDI OD associated with a reduction in cortical thickness, more cognitive dysfunction, and lower hippocampal and amyg dala volumes, as well as more compromised daily-living activities ID and discrimination more strongly associated than threshold SS measures with structural volumes UPSIT R scores lowest in AD, next lowest in MCI, and normal in HCs Scores were positively correlated with cognitive test scores among all patients fMRI olfactory network exhibited diminished activation in both MCI and AD, with more decrement in AD Smell loss > in early onset AD compared with MCI andHCs In AD, UPSIT R scores correlated > 0.49with Test scores lower in AD than in MCI and correlated with ADAS-Jcog scores OD associated with atrophy of the medial temporal lobe, including hippocampal and parahippocampal regions Based on different CERAD components, 6% to 11% of the sample were cognitively impaired Better olfactory performance was associated with better cognitive performance on all measures, although ability of the smell test to attention, executive function, and praxis measures

SS-TDI Cognitive

2019 4

Case

30 AD with OD 30 AD without OD

control

meaures MRI-determined structural volumes

Luet al 654

2019 4

Case

12AD 19MCI 31 matched HCs

Cognitive tests UPSIT R fMRI of multiple brain structures related to CNS neural

control

olfactory network

Velayudhan et al 655

UPSIT R Cognitive

2019 4

Case

19 early-onset AD

control

17MCI 21HCs

measures

Yoshii et al 656

2019 4

Case

55AD 27MCI

OSIT-J cognitive tests MRI

control

Yahiaoui-Doktor et al 657

2019 3

Cohort

6783 population sampled

SS-ID (12 odors) CERAD cognitive battery

discriminate between those with and without cognitive impairment was limited (Continues)