xRead - Olfactory Disorders (September 2023)

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INTERNATIONAL CONSENSUS ON OLFACTION

TABLE VII.12 (Continued)

Study design Study groups

Clinical end point

Topic

Study

Year LOE

Conclusions

Woodword et al 647

UPSIT R

2017 4

Case

262AD 110aMCI 194HCs

High sensitivity of UPSIT R for identifying AD and aMCI 34% of aMCI with impaired olfaction and 17.3% with intact olfaction converted toAD Those with high UPSIT R scores were less likely to have cerebral amyloidosis or memory decline 1092 diagnosed with MCI Those with OI had lower memory, language, executive function, and general cognitive performance OI was lower in MCI than innon-MCI OI more severe in AD and aMCI compared with naMCI and SMI groups Olfactory ID ability was nonverbal memory, and frontal executive function Identified subsets of UPSIT R items that individually associated with AD and age useful for assessing risks for AD Respective frequency of dysfunction in HC, MCI, and AD groups: SS – 3.3%, 13.5%, 65%; self-report – 10.3%, 13.5%, 18.3%; HRS – 6.7%, 24.3%, 48.3% AD with OD compared with AD without OD exhibited declines in global cognition and memory, visuospatial ability, and attention positively related to MMSE, verbal and

control

Kreisl et al 648

2018 4

Case

46aMCI 23HCs

UPSIT R PIB Amyloid- β PET measure

control

Palta et al 649

SS-ID (12 odors) Cognitive tests

2018 2

Cross

5021 community residents aged 45 to 64 years

sectional

Parket al 650

2018 4

Case

20mildAD 50aMCI 28naMCI 27SMI

B-SIT Cognitive tests

control

Woodward et al 651

415AD 192aMCI 234HCs Longitudinal

2018 3

Cohort and case

UPSIT R

control

prediction of ADfrom aMCI and ID of optimal UPSIT R items

Yuet al 652

2018 4

Case

60AD 37MCI 30HCs HRS Self-reported loss Cognitive measures

SS-TDI

control

(Continues)