xRead - Olfactory Disorders (September 2023)

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INTERNATIONAL CONSENSUS ON OLFACTION

TABLE VII.12 (Continued)

Study design Study groups

Clinical end point

Topic

Study

Year LOE

Conclusions

Kleinet al 669

UPSIT R

2021 2

Cross

54 normal and cognitively impaired PET imaging of tau in 41 and 18kDa

Low ID scores associated with greater tau pathology in medial temporal cortex, hippocampus, middle and inferior temporal gy, and posterior cingulate cortex MCI/AD scored less than HCs AROMA test superior toSS-IDin discrimination MCI could be differentiated fromAD SS-D differentiates HCs from AD and MCI Although intranasal anticholinergic challenge–induced initial odor ID decline, which reflects greater cholinergic deficiency, the decline was not associated with better cognitive efficacy from a 52-week treatment with a cholinesterase inhibitor This is a failure to replicate the findings of an earlier smaller study 640 Test scores lower in the high vs low aMCI groups independent of HAND status Scores were poorest for AD followed by MCI, SCD, andHCs In AD and MCI, SS-ID correlated with global cognition Among the different cognitive domains, SS-ID correlated most strongly with memory

sectional

translocator protein in 53

Li et al 670

2021 4

Case

24AD 24MCI 33HCs

AROMAtest SS-ID (12 odors)

control

Motter et al 671

2021 3

Cohort

100MCI

UPSIT R Changes in

ADAS-Cog total score and SRT total immediate recall from baseline to 52 weeks

Sundermann et al 672

2021 4

Case

31high

UPSIT R

control

aMCI + HAND

26 low

aMCI + HAND 4 high aMCI no HAND 20 low aMCI no HAND

Wanget al 673

SS-ID (16 odors) Cognitive tests

2021 4

Case

52AD 129MCI 84SCD 35HCs

control

(Continues)