xRead - Olfactory Disorders (September 2023)

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INTERNATIONAL CONSENSUS ON OLFACTION

TABLE IX.1 Prognosis and spontaneous recovery

Clinical end point Δ Subjective: unknown

Study

Year 1964

LOE Study design Study groups

Conclusions

Sumner 303

39% of patients with PTOD recovered at varied time but typically within 10 weeks except in rare cases (5 years for one) 14% of patients with PTOD recovered at varied times (case study with 7 years) No recovery for patients with PTOD and and those with PVOD, but some recovery for those with RS No percentages given 36% showed improvement, but this, along with duration, was not significant Change with age modeled, but not reported Improvement by etiology (AR > RS > PVOD > PTOD) Longer duration of disorder and sex (male) lead to worse prognosis in patients with PTOD and those with RS, but not in patients with PVOD No effect of age on prognosis Within a month, olfactory outcomes increased from day 0 to35 Congestion dependency was found in some, but not all, outcomes 32% of patients with PVOD and 10% of patients with PTOD improved in olfactory Age was negatively associated with improvement Improvement by etiology (RS/AR [31%] > PVOD(27%) > PTOD/idiopathic [18%]) Patients with PVOD had more parosmia, but this did not impact recovery Among all patients, sex (female), age, and duration of impairment impacted recovery Among patients with OD at initial assessment, etiology (RS/AR [49%] > PVOD[48%] > PTOD [44%] > idiopathic [34%]) impacted recovery

1167 patients 101 patients with PTOD (series)

4

Case series (within a year; 2 to 16 years)

Zusho 305

1982

4*

Retrospective

56 patients with PTOD

Δ Subjective: unknown

cohort (across 15 years)

Deems

306 patients with OD

ΔUPSIT R

1991

4*

Retrospective

et al 135

cohort (5 months to6years)

Doty

1997

4

Case series (1

248 patients with PTOD 66 patients with PTOD (series)

ΔUPSIT R Δ Questionaire

et al 312

months to 13 years)

Mori

889 patients with OD

ΔT&T

1998

4*

Retrospective cohort (2 months to unknown)

et al 1325

olfactometer

Hummel et al 1330

1998

2

RCT (0, 2, 4, 6, and 35 days)

12 AR controls 2) 12 patients with ARwith oxymetazoline (0.25 mg/mL) 12 patients with AR with oxymetazoline (0.5 mg/mL) 262 patients with PVOD 99 patients with PTOD

Δ Subjective sypmtoms SS-TDI Δ Rhinometry ΔcsERPs

Reden

SS-TDI

2006

3

Retrospective cohort (1 to 216 months)

et al 1328

Reden

2007

4*

Retrospective

392 patients with OD

ΔSS-TDI

et al 1327

cohort (no range given; mean 11 months)

London

542 patients with OD

ΔUPSIT R

2008

3

Retrospective cohort (3 to 283 months)

et al 1099

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