xRead - Olfactory Disorders (September 2023)

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545

PATEL et al.

TABLE IX.1 (Continued)

Clinical end point

Study

Year 2009

LOE Study design Study groups

Conclusions

Mueller and

5*

Case report

1 patients with PTOD 27 patients with PVOD

SS-TDI csERPs

Patient recovered after 9 years of subjective loss 26% of patients improved and csERPs had some predictive value (44% sensitivity, 83% specificity) Age and sex did not affect recovery Improvement by etiology (RS/AR [76%] > PVOD[46%] > PTOD [44%]) Lower age, increased parosmia, and sex (female) had increased recovery rates 36% of patients with PVOD and 25% of patients with PTOD improved in olfactory Larger bulbs related to better recovery 86% reported subjective improvement and unknown for threshold testing Mechansims underlying neurogenesis in the subgranular zone, the subventiricular zone, andOE Mechanisms underlying olfactory neurogenesis with age Age-related declines in olfactory ability along with regeneration decreases 16.8% recovered and no prognosis factors were relevant to recovery 37% of PVOD control improved For controls, duration of olfactory loss, but not age or sex, was related to improvement Horizontal basal cells contribute to OE damage and mechanisms are discussed List of interventions that have an impact on olfactory loss recovery Smell (and nasal dimensions) decreased during RS, but almost all patients improved on recovery No imporovement in retronsasal smell (Continues)

Hummel 1337

Rombaux et al 1342

2010 4

Case series (4 to 18 months)

ΔSS-TDI ΔcsERPs Δ Retronasal ID

Hummel and Lötsch 1324

ΔSS-TDI

463PVOD 220AR/RS 211PTOD

2010 4*

Retrospective cohort (1 to 106 months)

Rombaux et al 1071

2012

4

Case series (no range; mean 14.6 months)

28 patients with PVOD 32 patients with PTOD 63 patients with PVOD 20 controls

ΔSS-TDI ΔOBV Δ Retronasal ID

Lee

Δ Subjective: VAS, binary ΔBTT (n = 25)

2014

4

Case series (mean 33months)

et al 1322

Brannand

2014

1

Review

NA

NA

Firestein 1345

Mobley

2014

1

Review

NA

NA

et al 1343

Doty 522

2014

1

Review

NA

NA

Fan

107 patients with PTOD

ΔUPSIT R

2015

3

Retrospective cohort (1 to 52 months)

et al 1341

Konstantinidis et al 1336

2016

2

RCT (0, 8, 16, 25, 32, 40, 48, and 56 weeks)

41 patients with PVOD

ΔSS-TDI

36-short OT 34-longOT

Schwob

2017

1

Review

NA

NA

et al 155

Hummel et al 14

2017

1

Review

NA

NA

Pellegrino et al 1329

2017

3

Prospective cohort (21 to 90 days)

57 RS controls

ΔSS-TDI Δ Retronasal ID Δ Rhinometry