xRead - Olfactory Disorders (September 2023)

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PATEL et al.

TABLE IX-24 Section evidence summary: Treatment of underlying vitamin deficiency Study Year LOE Disease Study design Study groups

Clinical end point Conclusions

Acute zinc loss causedby histidine treatment caused olfactory and gustatory

Single olfactory and gustatory

Case series

6 patients with progressive

Henkin

1975

4

Zinc deficiency causedby histidine

et al 1503

function tests (pyridine for smell, urea for taste)

systemic sclerosis taking histidine

administration to treat progressive systemic sclerosis

amino acid: 4 female 2 male

dysfunction and treated rapidly with zinc admin istration

Jafek

2004 4

Anosmia after zinc gluconate

Case series

n = 10

Colorado CS

Zinc-induced anosmia

et al 376

questionaire

occurs after exposure to OE

Alexander and Davidson 377

Case series

(n = 17)

UPSIT R

2006 4

Zinc-induced anosmia syndrome

Zinc-induced anosmia

occurs after the exposure of zinc cation to OE

Garrett-Laster et al 1510a

1984 4

Vitamin A–deficient patients (n = 27) treated with oral vitamin A (10,000 μ g/day) for 4 weeks posttraumatic anosmia treatment with systemic vitaminA Postinfectious,

Descriptive (noncon trolled)

37 Vitamin A

Pyridine detection and recognition threshold improvement

Significant

deficient patients

improve ment in olfactory threshold

SS-TDI

Systemic

52 patients (n = 26 placebo, n = 26 systemic vitamin A, 10,000 IU, 3 months)

Reden

Double-blind

2012 2

et al 456

application of vitamin A not useful for treatment of postinfec

randomized, controlled clinical

tious or posttrau matic olfactory loss

Hummel et al 457

2017

4

Postinfectious anosmia

Retrospective cohort

170 patients (n = 46 smell training only, 124 smell training + intranasal vitamin A, 10,000 IU

SS-TDI

Intranasal

vitaminA could potentially be useful for treatment of postinfec tious olfactory loss but more robust dataare needed

treatment with smell training and intranasal vitamin A

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