xRead - Olfactory Disorders (September 2023)

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594

INTERNATIONAL CONSENSUS ON OLFACTION

TABLE IX-29 Use of OT to treat OD Study Year

LOE Study design

Study groups

Clinical end point

Conclusions

SS-TDI

All studies reported clinically significant results after OT OT had an odds ratio of

Kattar

2020

1

Systematic review and meta-analysis

OT forPIOD 16 studies included 4 in meta-analysis

et al 250

2.77 of achieving MCID vs control Strong significant

Sorokowska et al 1484

2017

1

Systematic review and meta-analysis

13 studies

SS-TDI

relationship with OT and discrimination and identification, and overall TDI score improvement PIOD has the strongest relationship with improvement OT improves TDI (3.77, mean difference) Discrimination and identification improved, but not threshold Odds ratio of MCID 2.75 OT was effective in all 10 identified studies

Pekala

2016

1

Systematic review and meta-analysis

10 studies 3 for meta-analysis

Olfactory

et al 1543

improvement using psychophysical tests

Hura

2020

1

Systematic review (EBRR) for PIOD

10 studies for OT Effectiveness of OT, medical therapy

et al 374

Addison and Philpott 1552

2018

1

Systematic review 1 meta-analysis, 6 studies

Effectiveness of OT, medical therapy

OT is effective for

improving olfaction in olfactory loss

Langdon et al 1066

2018

2

Prospective, RCT

42 patients with PTOD OT with 6 odors for 12weeks (n = 21) Controls (n = 21)

UPSIT R BAST-24 n-butanol threshold VAS

No significant difference in

UPSIT R , BAST-24, VAS 26% vs 5% met MCID for n-butanol

threshold at 12 weeks, but not sustained at 24 weeks

Patel

UPSIT R

2017

2

Prospective, RCT

43 patients with PIOD or IOD for > 12months OT with 4 essential oils for 26 weeks (n = 19) Controls (n = 16) 171 patients with PIOD for 2 to 24 months High concentration COT(n = 70) Low concentration COT(n = 74) Crossover at 16 weeks

32% in OT group (vs 13% in control group) had > 10% improvement on UPSIT R TDI improved by 3.0 in thehigh concentration group vs 2.8 in the low concentration group at 16weeks 26% vs 15% met MCID 53% vs 34% subjective improvement at 32 weeks

et al 1544

Damm

2014

2

Prospective, blinded randomized controlled multicenter

SS-TDI 5-point subjective ranking scale

et al 1541

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