xRead - Olfactory Disorders (September 2023)

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595

PATEL et al.

TABLE IX-29 (Continued) Study Year

LOE Study design

Study groups 83 patients with PTOD

Clinical end point

Conclusions

PEA threshold UPSIT R -TC MRIOBV

PEA threshold: 24% improved in OT group vs 5% in controls No difference in UPSIT R orOBV TDI improved by 5.7 and 6.6 in groups, withMCID Discrimination and identification also improved in both, but no change in threshold TDI improvement Discrimination also had greater improvement Adherence to therapy 63%vs 30% improvement in PEA threshold UPSIT R improved in the PEA group ( + 1.6), but not in COT MRI not different between groups No effect of training regimen on recovery Overall, TDI improved for all groups Threshold and identification improved, but not discrimination improvement in 41% in both at 6 months greater in training ball group (6 vs 3.7) Both groups had

Jiang

2017

2

Prospective, RCT

et al 1553

OTwith: PEA(42) Mineral oil (n = 39) for 3 months 125 patients with PIOD COT(n = 60) Household OT (n = 65) (balm, vinegar, alcohol, rose perfume) for 24weeks 60 patients with PIOD OT training ball with 4 scents (n = 30) Modified OT (n = 30) (Altundag) for 12 weeks 111 patients with PTOD COT(n = 45) PEA alone (n = 45) for 6 months 108 patients with PIODor IOD 4odors (n = 30) 4 odor mixtures (n = 23) 3 × 4odors, changing every 2 months (n = 20) OT done for 4 to 12 months

Qiao

2020

2

Prospective,

SS-TDI

et al 1550

randomized

Saatci et al 1546

SS-TDI Adherence to OT

2020

2

Prospective,

randomized

Jiang

2019

2

Prospective,

UPSIT R -TC PEA threshold MRIOBV

et al 1548

randomized

SS-TDI

Oleszkiewicz et al 1547

2018

2

Prospective,

randomized

Poletti

2017

3

Prospective,

96 patients with

SS-TDI PEA threshold

PIODMCID

et al 1549

pseudorandomized, single-blinded

PIOD(n = 70) andPTOD(n = 26) molecule (n = 48) low weight molecule (n = 48)OT for 5 months

improvement 3 × PTOD (45% vs 16%)

Only difference

Heavy weight

between heavy weight molecule and low weight molecule odors were found for threshold in PIOD

OthersNS

(Continues)