xRead - Olfactory Disorders (September 2023)

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596

INTERNATIONAL CONSENSUS ON OLFACTION

TABLE IX-29 (Continued) Study Year

LOE Study design

Study groups

Clinical end point

Conclusions

SS-TDI Subjective OF

Improvement in TDI of 9.1 for 16 weeks, 11.4 for 56 weeks, 5.3 for control (58% vs 71% vs 37% meeting MCID) Identification only significant subgroup Improvement in TDI of 4.6 vs 2.7 for controls Threshold improved by 2.1 vs 0.7 in controls Identification improved by 1.6 vs 0.8 in controls No difference in discrimination TDI improved by 5.5 withOT Increased volume of gray matter in hippocampus, thalamus, and cerebellum after OT No improvement on overall composite TDI 35% met MCID improvement EOG response to PEA and hydrogen sulfide improved with OT improved recovery vs standard OT 56% met MCID vs 46% vs none in controls (TDI 8.2 vs 6.1 vs 1.7) Improvement seen in discrimination and identification domains VAS 5.6 vs 5.2 vs 2.8 Improvement seen in both groups vs control, more in PIO Improvement seen in discrimination and identification domains (TDI 6.25 vs 1.5 PIOD, 5.1 vs 1.2 posttraumatic olfactory loss) Subjective ratings also improved in OT groups Changing odors

111 patients with PIOD COT for 16 weeks (n = 36) COT for 56 weeks (n = 34) Controls (n = 41) 104 patients with PIOD OT with rose, lemon, cinnamon, 30 patients with PIOD 31 normosmic controls COT for 12 weeks 50 patients with PIODor idiopathic loss COT for 16 to 24 weeks (n = 23) Controls (n = 27) 85 patients with PIOD Three sets of 4 odors (n = 37) 4odors (n = 33) Controls (n = 15) for 36 weeks Controls (n = 64)

Konstantinidis et al 1336

2016

3

Prospective, partially randomized, controlled

Choi

2021

3

Prospective cohort

Korean SS-TDI VAS

et al 1554

orange, peach for 12weeks (n = 40)

Gellrich

SS-TDI Gray matter volume onMRI

2018

3

Prospective cohort

et al 1084

Hummel et al 1285

2018

3

Prospective cohort

SS-TDI EOG

Altundag et al 1545

SS-TDI VAS

2015

3

Prospective cohort

Konstantinidis et al 1346

2013

3

Prospective cohort

119 patients with PTOD(n = 38) andPIOD(n = 81) COT with 4 odors (n = 72) Controls (n = 47) for 16 weeks

SS-TDI Subjective olfaction

(Continues)