xRead - Olfactory Disorders (September 2023)

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PATEL et al.

TABLE VII.4 Section evidence summary: AR or non-AR related olfactory loss Study Year LOE Study design Study groups

Clinical end point

Conclusions

Olsson et al

2003 2

Cross-sectional

10,670 adults

Self-reported questionnaire In a population study, 19% of individuals reported symptoms consistent with non-AR, while 24% reported AR. Subjective hyposmia was reported by ≈ 30% in non-AR, 13% in AR, and 12% in healthy individuals

Rhee et al

2014 2

Cross-sectional

2305 participants

IgE testing Health survey

Prevalence of AR was 16% Odds ratio of OD for those with AR of 4.88 compared with a healthy population

2015 2 *

Stuckand

Effect of AR on olfaction OD in AR ranges from 20% to 40%, typically mild to moderate

Systematic review 36 studies

Hummel

N = 17 to 10,670 patients

Aksoyet al

2018 3

Case-control

44 pediatric patients with seasonal AR

CCCRC olfactory test Subjective olfactory assessment Acoustic rhinometry Allergy prick testing

CCCRC olfactory test scores significantly decreased during allergy season, which correlated with subjectively reported hyposmia Nasal volume decreased during allergy season but there was no correlation between CCCRC olfactory test score and acoustic rhinometry Self-reported OD in pediatric patients with AR is associated with severe and uncontrolled disease 44% of patients exhibited self-reported OD, which was positively correlated with the severity of disease No significant difference in odor scores was found between groups or based on severity; however, odor identification and total odor scores were lower in patients with symptoms for > 3years At baseline, 67.9 % of patients were normosic, 23.7% were hyposmic, and 8.4% were anosmic Patients with AR exhibited lower olfactory-related QOL scores compared withHCs

Mariño-Sanchez et al

2018 4 Cross-sectional

142 pediatric patients with persistent AR

Self-reported VAS

Langdon et al

2016 3

Cross-sectional

1260 pediatric patients with AR (CRS not excluded)

Questionnaire with

self-reported symptoms

SS-TDI

Kutlug et al

2016 4 Case-control

Control group: 45

pediatric patients AR: 42 pediatric patients Non-AR: 35 pediatric patients

Katoto

2015 3

Cross-sectional

Control group: 48 healthy patients Placebo-control group: 45 patients with AR Treatment group: 145 patients with AR

SS-TDI Questionnaire of Olfactory Deficits QOL surveys

michelakis et al

(Continues)