xRead - Olfactory Disorders (September 2023)

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PATEL et al.

TABLE VII.7a (Continued) Study Year LOE

Study design Case-control

Study groups OBof: 35 residents of Mexico City exposed to

Clinical end point UPSIT R Light and electron microscopy of the OB

Conclusions Mexico City

Calderón

2010

4

residents had worse UPSIT R scores and OB pathology findings including endothelial hyperplasia and neuronal accumulation of particles

Garcidueñas et al 349

severeair pollution

9 controls UPSIT R scores of: 62 residents of Mexico City 25 controls

Lucchini et al 331

2012

4

Cross-sectional

154 adolescents aged 11 to 14

Motor coordination (Luria-Nebraska test) Hand dexterity (Aiming Pursuit test) Odor identification (SS-ID) Tremor intensity

Exposure to

manganese was associated with deficits in olfactory and motor function

years residing in Valcamonica, Italy (a region impacted by ferroalloy plant manganese and other metals for a century), or a reference area reference area (n = 157) emissions containing

Controls in a

Sorowska el al 355

SS-T

Dresden residents performed worse

2013

4

Cross-sectional

151native

Amazonians 286 residents living

inDresden (higher air pollution)

Grashow et al 356

2015

4

Cross-sectional

165 men from the Normative Aging Study who previously had bone lead measurements

UPSIT R score Global cognition (Mini-Mental Status Examination) Cumulative lead exposure

Cumulative

exposure to lead is associated with reduced olfactory recognition This was attenuated in men with better cognitive function

Adams

2016

4

Cross-sectional

Respondents from theNSHAP

Validated odor

Increase in nitric

et al 348

identification test

dioxide exposure was associated with increased odds ofOD

Riccó

2016

4

Cross-sectional

66 workers exposed to phenolic resins

Self-reported olfactory impairment (hyposmia, anosmia, hyperosmia)

31.8% had hyposmia, 18.2%had anosmia, and 13.6%had hyperosmia

et al 357

(Continues)