April 2020 HSC Section 4 - Plastic and Reconstructive Problems

J A M A CAD D ERMATOL V OLUME 77, N UMBER 1

Adil and Godwin

Results, mean difference hair density/cm 2 (SD) * between baseline and follow-up

Continued

48 Minoxidil 5%: 18.6 (25.4) Placebo: 3.9 (21.7)

48 Minoxidil 2%: 20.7 (17.6) Placebo: 9.4 (14.6)

32 Minoxidil 2%: 22.7 (69) Placebo: 10.1 (55)

32 Minoxidil 2%: 33.1 (58) Placebo: 19.1 (65)

32 Minoxidil 2%: 28 (29) Placebo: 20 (18)

Follow-up, weeks

Article Sex Study population details Intervention group Control Placebo N = 71

Placebo

N = 51

Placebo

N = 128

Placebo

N = 139

Placebo

N = 13

Minoxidil 5% applied twice daily N = 139

(1 mL) applied twice daily N = 108

(1 mL) applied twice daily N = 128

Minoxidil 2% applied twice daily N = 155

(1 mL) applied twice daily N = 15

Minoxidil 2% topical

Minoxidil 2% topical

Minoxidil 2% topical

Olsen et al 2002a 14 Men Mean age: 36.5 years Exclusion: systemic illness, hypersensitive to minoxidil, concomitantly use of hair restorers or systemic drugs Race: 79% white, 17% Hispanic AGA type: 3-6 on Savin Scale Lucky et al 2004 15 Women Mean age: 37 years

Inclusion: Female-pattern hair loss, hair density rating of 4-7 on the Savin Female Density Scale

Exclusion: systemic illnesses, pregnant or breast feeding, hypersensitive to

minoxidil, use of hair restorers or systemic drugs Race: 74% white

AGA type: 97% had Ludwig grade I or II hair loss. Exclusion: N/S

Exclusion: previously use of topical minoxidil, pregnant or breast feeding, use of hair restorers or systemic drugs within the past 3 months Race: 91% white AGA type: Ludwig grade I or II

Exclusion: cardiac, scalp, systemic disease; previous use of topical minoxidil;

pregnancy or breastfeeding; use of hair restorers or systemic drugs within the past 3 months Race: 85% white AGA type: Ludwig grade I or II

Race: 86% white AGA type: Ludwig grade I or II

Supplementary Table I. Cont’d

DeVillez et al 1994 16 Women Mean age: 34 years

Jacobs et al 1993 17 Women Mean age: 33.7 years Whiting and Jacobson 1992 18

Women Mean age: 34 years

95