April 2020 HSC Section 4 - Plastic and Reconstructive Problems

Aesth Plast Surg (2015) 39:495–505

Table 2 Significant findings in studies review, broken down by study type and platelet preparation used

PRP

L-PRP

PRFM

In vitro studies Rughetti et al. [ 4 ] Kakudo et al. [ 5 ]

Induced proliferation of endothelial cells

Promoted proliferation of adipose-derived stem cells and dermal fibroblasts

Giusti et al. [ 7 ] Stimulated angiogenesis in endothelial cells Mishra et al. [ 8 ] Promoted proliferation of mesenchymal stem cells Kim et al. [ 10 ] Increased levels of procollagen type I Kushida et al. [ 9 ] Promotes proliferation of dermal fibroblasts, promotes wound contraction Kakudo et al. [ 6 ] Stimulated proliferation of endothelial cells Atashi et al. [ 12 ] Shin et al. [ 14 ] Up-regulated expression of MMP-1 and type I collagen in dermal fibroblasts Liu et al. [ 26 ] Increased proliferative capacity, restored cell senescence markers, and resisted oxidative stress in stem cells Tajima et al. [ 11 ] Increased growth factor secretion by adipose- derived stem cells Roubelakis et al. [ 15 ] Promoted migration and proliferation of mesenchymal stem cells and dermal fibroblasts Amable et al. [ 13 ] 5–10 9 increased cell proliferation Por et al. [ 23 ] No effect on increasing free fat graft survival in mice Pires et al. [ 19 ] Increased survival of free fat grafts in rabbits Nakamura et al. [ 20 ] Promoted survival of fat grafts in rats Giovanni et al. [ 35 ] Increased granulation tissue, decreased bone deposition in cranial defects, increased type III: type I collagen ratio, increased CD34 ? chemotaxis Giovanni et al. [ 36 ] Diminished bone repair, increased fibrous tissue deposition, increased type III: type I collagen ration Cho et al. [ 17 ] Reduced wrinkles in mice, increased fibroblasts and collagen Oh et al. [ 18 ] Improved fat graft survival in mice Rodriguez- Flores et al. [ 21 ] Increased maintenance of transplanted fat cells Kawazoe and Kim [ 33 ] Animal studies Sclafani et al. [ 1 ] Farrag et al. [ 16 ] Chandra et al. [ 24 ] Improved wound healing and tissue ingrowth in implanted grafts Neurotrophic effect on facial nerve after repair Increased overall inflammation in skin flap wound; no difference in collagen deposition

Dose dependent, promoted proliferation of mesenchymal stem cells

Greater tissue augmentation in mice with L-PRP

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