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Wise et al.

Page 289

TABLE II.A-1.

Aggregate grade of evidence 6

Author Manuscript Author Manuscript Author Manuscript Author Manuscript Grade C

Research quality

A Well-designed RCTs B

RCTs with minor limitations; Overwhelming consistent evidence from observational studies

Observational studies (case control and cohort design) D Expert opinion; Case reports; Reasoning from first principles

RCT = randomized controlled trial.

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.