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Wise et al.

Page 290

Author Manuscript Author Manuscript Author Manuscript Author Manuscript benefit

Preponderance of harm over

Strong recommendation against

Recommendation against

TABLE II.A-2. American Academy of Pediatrics-defined strategy for recommendation development 6 Evidence quality Preponderance of benefit over harm Balance of benefit and harm A. Well-designed RCTs Strong recommendation Option B. RCTs with minor limitations; overwhelmingly consistent evidence from observational studies C. Observational studies (case-control and cohort design) Recommendation D. Expert opinion; case reports; reasoning from first principles Option No recommendation RCT = randomized controlled trial.

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.