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Wise et al.

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Reported association with other allergic diseases Protein function LOE

Author Manuscript Author Manuscript Author Manuscript Author Manuscript TABLE VI.A. Nearby

LRRC32: T-cell regulation, TGF- β activity. C11orf30:

2712 AR cases; 2921 controls EA, L, AA rs17133587 4.5E–09 (L) AKR1E2 No NAD(P)H-dependent oxidoreduction rs6583203 1.4E–08 (L) DLG1 No Scaffolding protein involved in cell metabolism groups) FERD3L No Transcription factor

company data (23andMe) 46,646 total >97% EA rs1438673 3.7E–19 WDR36 Asthma 487, 513 ; eczema 488 ; atopy 487 Cellular processes and T-cell activation Nested case 1132 AR

rs2101521 6.0E–17 TLR1–TLR6 ; TLR10 Asthma, eczema, atopy 487 Pathogen recognition and activation of innate immunity rs10189629 9.9E–15 IL1RL2 ; IL1RL1 Asthma 487, 514 ; eczema 487 ; atopy 487 Proinflammatory effects, T helper cell function

cases; 997 controls Chinese rs811930 7.3E–05 MRPL4 No Protein synthesis within the mitochondrion 3933 AR

rs505101 1.3E–04 BCAP (PIK3AP1 ) Atopy 515 Protein tyrosine kinase

regulation of viral immunity and interferon pathways

rs17513503 7.4E–07 TMEM232 No Transmembrane protein

rs1044573 9.7E–07 ENTPD6 No Catabolism of extracellular nucleotides

EA, L, AA rs4833095 4E–12 TLR1 Asthma, eczema, atopy 487 Pathogen recognition and activation of innate immunity rs2155219 7E–10 LRRC32 or C11orf30 Co-morbidity: asthma atopy 489 ; asthma eczema 491 ; asthma-hay fever 486 See above

Co-morbidity: asthma atopy 489 ; asthma eczema 491 ; asthma-hay fever 486 Eczema, 487, 490 asthma, atopy 487

cases; 8965 controls EA rs2155219 3.8E–08 LRRC32 or C11orf30, SLCA25A46

gene(s)

Top SNPs for AR p

rs7780001 2.0E–08 (all

16,513 hay

fever cases; 17,256

controls

Key findings from GWASs on allergic rhinitis or hay fever Author (year) Study design Sample size Ethnicity Bunyavanich et al. 512 (2014) Meta-analysis of 7 cohorts Hinds et al. 487 (2013) Private

control with replication

Meta-analysis of 4 cohorts

Meta-analysis of 4 cohorts/ datasets

Ferreira et al. 486 (2010)

Andiappan et al. 515 (2011)

Ramasamy et al. 488 (2011)

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.