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Wise et al.

Page 297

ORs are unadjusted and reported with 95% CIs. AR = allergic rhinitis; CI = confidence interval; COPSAC = Copenhagen Prospective Study on Asthma in Childhood; Der p = Dermatophagoides pteronyssinus ; Der f = Dermatophagoides farinae ; LOE = level of evidence; MAAS = Manchester Asthma and Allergy Study; OR = odds ratio; PAULA = Perinatal Asthma and Environment Long-term Allergy; PIAMA = Prevention and Incidence of Asthma and Mite Allergy; SAR = seasonal allergic rhinitis.

Author Manuscript Author Manuscript Author Manuscript Author Manuscript TABLE VI.B-1. Evidence for the effects of mite allergen exposure (in utero and early childhood exposure) on the development of allergic rhinitis * Study Year LOE Study design Study groups Type of exposure Conclusion Schoos et al. 518 2016 2b Prospective birth cohort 399 children (7–13 years old) from COPSAC study Der p 1 in dust sample at 1 year No association with AR at 7 years (OR 0.9; 95% CI, 0.7–1.1). Der f 1 in dust sample at 1 year No association with AR at 7 years (OR 0.9; 95% CI, 0.7–1.1). Illi et al. 517 2014 2b Prospective birth cohort 513 children (5 years old) from PAULA study Mite allergen exposure at 3 months (measured as allergen levels in the living room floor and in the mother’s or child’s mattress) No association with current AR (OR not reported). Marinho et al. 520 2007 2b Whole-population birth cohort 815 children (5 years old) from MAAS study Der p exposure at 0–5 years old (measured as allergen levels recovered from child’s bed, child’s bedroom floor, parental bed, and lounge floor) Protective factor for current rhinoconjunctivitis (OR 0.8; 95% CI, 0.7–0.98). This finding failed to reach significance in multivariate analysis. Corver et al. 516 2006 2b Prospective birth cohort 416 children (4 years old) from PIAMA study Der p 1 and Der f 1 exposure on the children’s mattresses No association with rhinitis in 4th year (OR 0.9; 95% CI, 0.6–1.3). Kulig et al. 468 2000 2b Prospective birth cohort 587 children (7 years old) from MAAS study Mite (Der p 1 + Der f 1) exposure at 0–18 months (measured as allergen levels obtained from carpet dust samples) No association with SAR (OR not reported). Kim et al. 521 2002 3b Cross-sectional 16,624 children (7–18 years old) History of spider mite exposure Risk factor for rhinitis (OR 1.3; 95% CI, 1.2–1.5). *

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.