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Wise et al.

Page 300

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Study Year LOE Study design Study groups Type of exposure Conclusion a and dog 0.8; 95% CI, 0.4–1.4); (OR bird only 1.3; 95% CI, 0.9–1.8); (OR rodent only 0.8; 95% CI, 0.5–1.5). Lampi et al. 532 2011 2b Prospective birth cohort 5509 adults (31 years old) Maternal work with farm animals (cows, pigs, sheep, poultry, minks) during pregnancy No association with AR (OR 0.9; 95% CI, 0.7–1.2). Sandini et al. 549 2011 2b Prospective birth cohort, RCT 1223 children (5 years old) born to allergic families, who participated in a RCT Dog/cat at home at 0–2 years old or 0–5 years old Chen et al. 547 2007 2b Prospective birth cohort 2166 children (4–6 years old) (hay fever: 66/1599) from LISA study birth cohort

No association with AR (OR 0.98; 95% CI, 0.5–1.8).

No association with doctor-diagnosed hay fever (OR parents’ mattress 0.9; 95% CI, 0.5–1.5); (OR children’s mattress 0.7; 95% CI, 0.4–1.1).

No association with current rhinoconjunctivitis (unadjusted OR cat 1.02; 95% CI, 0.9–1.1); (unadjusted OR dog 1.03; 95% CI, 0.9–1.2).

Nafstad et al. 524 2001 2b Birth cohort 2531 children (4 years old) Cat keeping at birth No association with AR (OR 0.5; 95% CI, 0.2–1.4). Dog keeping at birth No association with AR to grass/pollen (OR 0.8; 95% CI, 0.4–1.6). Kulig et al. 468 2000 2b Prospective birth cohort 587 children (7 years old) from MAAS study Cat (Fel d 1) exposure at 0–18 months (measured as allergen levels obtained from carpet dust samples) No association with SAR (OR not reported).

Pets in household (at 18 months) No association with SAR (OR not reported).

Cat allergen exposure at 3 months (measured as Fel d 1 levels from children’s or parents’ mattress)

Cat and dog exposure at 0–5 years old (measured as allergen levels recovered from child’s bed, child’s bedroom floor, parental bed and lounge floor)

815 children (5 years old) from MAAS study

Marinho et al. 520 2007 2b Whole-population

* Level 2b studies are listed in the table. Level 3b studies are referenced. a All ORs are adjusted unless differently specified and are reported with 95% CIs in parentheses. AR = allergic rhinitis; CI = confidence interval; COPSAC = Copenhagen Prospective Study on Asthma in Childhood; Fel d = major cat allergen; LISA = Lifestyle-Immune-System-Allergy; LOE = level of evidence; MAAS; Manchester Asthma and Allergy Study; OR = odds ratio; PAULA = Perinatal Asthma and Environment Long-term Allergy; RCT = randomized controlled trial; SAR = seasonal allergic rhinitis.

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.