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Wise et al.

Page 313

Author Manuscript Author Manuscript Author Manuscript Author Manuscript TABLE VII.A.1.

Effect of allergic rhinitis on general and disease-specific quality of life Study Year LOE Study design Study groups Clinical endpoint Conclusion Bousquet et al. 674 2013 1b RCT AR (n = 716): 1 Desloratadine (n = 360); 2 Placebo (n = 356) Symptoms scores, sleep questionnaire, RQLQ, WPAIAS Desloratadine improves symptoms, QOL, and functional impairment. Tatar et al. 672 2013 1b RCT AR (n = 56): 1 Mometasone(n = 14); 2 Mometasone + levocetirizine (n = 21); 3 Mometasone + montelukast (n = 21) Mini-RQLQ QOL significantly affected by AR. Combination of mometasone with levocetirizine or montelukast improves QOL more than mometasone alone. Yamada et al. 673 2012 1b RCT, double-blind, crossover PAR (n = 57): mometasone TSS, QOL score, sleep quality, nasal nitric oxide Hoiby et al. 678 2010 1b RCT AR (n = 53): 1 SCIT (n = 27); 2 Placebo (n = 26) Symptom and medication scores crossover AR (n = 584):

Nasal mometasone improves nasal symptoms, QOL, and sleep quality and decreases nitric oxide. SCIT reduces symptom and medication scores compared to placebo.

Desloratadine improves RQLQ and symptom score significantly compared to placebo.

1 Acupuncture (n = 487); 2 Control (n = 494) SF-36 Acupuncture improves QOL more than control at 3 months. Brinkhaus et al. 680 2008 1b RCT AR (n = 5237):

RQLQ, SF-36 QOL significantly affected by AR. Acupuncture group improves more than conventional medical care.

RQLQ, SF-36 QOL significantly affected by AR. Levocetirizine improves QOL compared to placebo.

RQLQ, symptom score

1 Desloratadine (n = 293); 2 Placebo (n = 291)

1 Randomized to acupuncture (n = 487); 2 Conventional medical care (n = 494); 3 Not randomized but received acupuncture (n = 4256)

1 Levocetirizine (n = 278);

Holmberg et al. 676 2009 1b RCT, double-blind, Witt et al. 692 2009 1b RCT AR (n = 981):

Canonica et al. 677 2006 1b RCT, double-blind AR (n = 551):

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.