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Wise et al.

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Author Manuscript Author Manuscript Author Manuscript Author Manuscript TABLE VIII.E.1.

SPT for D. pteronyssinus and D. farinae were 90.4% and 86.4% sensitive and 99.5% and 93.1%, specific, respectively. This compared to sensitivity of 96.3% and 88.9% and specificity of 96.2% and 88.9% of specific IgE assay, respectively.

Evidence for the role of skin-prick testing in the diagnosis of allergic rhinitis Study Year LOE Study design Study groups Clinical endpoint Conclusion Nevis et al. 830 2016 1a Systematic review and meta-analysis Not applicable Accuracy of SPT Pooled estimate for SPT sensitivity and specificity was 85% and 77%, respectively. SPT is accurate in discriminating subjects with or without AR. Gungor et al. 833 2004 3b Prospective case-control 1 Nasal provocation test positive; 2 Nasal provocation test negative Sensitivity and specificity of SPT vs SET for diagnosing AR SPT more sensitive (85.3% vs 79.4%) and specific (78.6% vs 67.9%) than SET as a screening procedure for multiple antigens. SPT had a greater PPV (82.9% vs 75%) and NPV (81.5% vs 73%) than SET. None of these differences were statistically significant. Krouse et al. 831 2004 3b Prospective case-control 1 Alternaria SPT positive; 2 Alternaria intradermal #2 dilution positive; 3 Alternaria negative Acoustic rhinometry of minimal cross-sectional area of nasal cavity Analysis of nasal provocation test results among groups showed a sensitivity of 42% and specificity of 44% for SPT using Alternaria antigen. Krouse et al. 832 2004 3b Prospective case-control 1 Timothy grass SPT positive; 2 Timothy grass intradermal #2 dilution positive; 3 Timothy grass negative Acoustic rhinometry of minimal cross-sectional area of nasal cavity case-control

Analysis of nasal provocation test results among groups showed a sensitivity of 87% and specificity of 86% with multi-test application of Timothy grass antigen.

On SPT with cat antigen, a wheal size of ≥3 mm had a sensitivity of 100% and specificity of 74.1%. This improved with increasing size of wheal.

SPT and RAST values exhibited excellent efficiency in diagnosis of cat allergy. Intradermal testing added little to the diagnostic evaluation. Sensitivity and specificity of SPT were 79% and 91%, respectively.

Sensitivity of fluoroenzyme immunoassay was significantly higher than SPT and IgE. However, SPT was more specific and had a better PPV. SPT was the most efficient test to diagnose AR.

testing to SPT and specific IgE assay for D. pteronyssinus and D. farinae

Wheal size that best identifies clinical allergy to cat based on nasal provocation testing

Perennial rhinitis patients Compared sensitivity and specificity of intradermal

Compared the predictive values of SPT, intradermal testing, and RASTs in the diagnosis of cat allergy

Compared the sensitivity, specificity, PPV, and NPV of SPT, IgE levels, and

fluoroenzyme immunoassay in diagnosing AR

1 Nasal provocation test positive;

2 Nasal provocation test negative

Patients with cat allergy determined by history and a cat-exposure model

A randomly selected sample of 8329 Swiss adults

case-control

case-control

case-control

Zarei et al. 834 2004 3b Prospective

Pumhirun et al. 835 2000 3b Prospective

Wood et al. 793 1999 3b Prospective

Tschopp et al. 822 1998 3b Prospective

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.