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Wise et al.

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Study Year LOE Study design Study groups Clinical endpoint Conclusion Seidman et al. 761 2015 5 Guideline Not applicable Not applicable Clinicians should perform and interpret or refer for specific IgE (skin or blood) allergy testing for patients with a clinical diagnosis of AR who do not respond to empiric treatment or the diagnosis is uncertain. Heinzerling et al. 836

2013 5 Review Not applicable Not applicable SPT is a reliable method to diagnose AR with specificity of 70% to 95% and sensitivity of 80% to 90% for inhalant allergies. Further standardization of SPT is needed. Bernstein et al. 818 2008 5 Practice parameter

Not applicable Not applicable Sensitivity of SPT ranges from 85% to 87% while specificity is 79% to 86%. Many studies have verified the sensitivity and specificity of SPT.

AR = allergic rhinitis; IgE = immunoglobulin E; LOE = level of evidence; NPV = negative predictive value; PPV = positive predictive value; RAST = radioallergosorbent test; SET = skin endpoint titration; SPT = skin prick test/testing.

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.