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Wise et al.

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Study Year LOE Study design Study groups Clinical endpoints Conclusion after 7 days of methylprednisolone 24 mg per day Cook et al. 868 1973 1b Double blind randomized controlled study

All antihistamines suppressed wheal size to varying degrees. Hydroxyzine suppressed

responses for 4 days after cessation vs 2 days for diphenhydramine.

Isik et al. 874 2011 2b Cohort Patients on SSRIs for depression (n = 24) Histamine-induced and allergen-induced prick test wheal responses before and after starting SSRI treatment. SSRIs fluoxetine, sertraline, and escitalopram did not significantly affect skin prick whealing responses. Corren et al. 875 2008 2b Cohort PAR patients (n = 40) Dust mite allergen skin test reactivity Gradman & Wolthers 885

Omalizumab (anti-IgE) therapy significantly reduces allergy skin test reactivity.

Topical mometasone and tacrolimus significantly reduced SPT wheal diameter.

Topical mometasone also reduced histamine induced wheal, while tacrolimus did not.

Topical clobetasol inhibited skin prick whealing response to histamine at the site of

topical steroid application in a dose-dependent and duration-dependent manner.

Zafirlukast did not suppress histamine-induced or allergen-induced wheal and flare response.

Systemic steroid therapy does not alter SPT reactivity to codeine or allergen.

All antihistamines suppressed SPT wheal response to histamine. Duration of suppression exceeded 72 hours for all agents tested.

Desipramine inhibits wheal response for 2 days; doxepin inhibits wheal response for 4 days.

Antihistamines varied in their ability to suppress SPT wheal response. Administration of hydroxyzine for 3 weeks leads to reduced skin test suppression for the antihistamines tested, suggesting induction to tolerance to antihistamine effects.

AR patients (n = 18 adults) Intradermal wheal size suppression after 3 day course of chlorpheniramine,

tripelennamine, promethazine, hydroxyzine, and diphenhydramine

(titrated prick tests) before during and after omalizumab therapy.

crossover cohort Atopic eczema patients (n = 12 children) SPT for 10 allergens before and after active treatment with topical mometasone or topical tacrolimus. Skin test sites were presumably treated daily for a total of 2 weeks.

Narasimha et al. 882 2005 2b Cohort 26 subjects Effect of topical clobetasol application on histamine-induced wheal response. Cuhadaroglu et al. 877 2001 2b Cohort 1 Asthma/AR patients (n = 9); 2 Controls (n = 8)

SPT to histamine and allergens before and after zafirlukast 20 mg BID for at least 5 days.

Codeine and dust mite induced SPT response with or without exposure to long term systemic steroids.

Almind et al. 867 1988 2b Cohort Healthy individuals (n = 23) Effect on histamine SPT wheal size after 2 day treatment with dexchlorpheniramine, cyproheptadine, astemizole, loratadine, terfenadine. Duration of SPT wheal suppression after cessation.

Rao et al. 873 1988 2b Cohort Healthy subjects (n = 33) Histamine prick tests for 1 week after single dose of desipramine or doxepin.

Effect of 6 different antihistamines on SPT wheal and flare reaction to histamine or

morphine or relevant aeroallergen. Effect of hydroxyzine and chlorpheniramine on skin test responses to other antihistamine classes.

Des Roches et al. 878 1996 2b Cohort 1 Steroid-dependent asthma patients (n = 33);

2 Asthma and/or AR (n = 66)

Long et al. 863 1985 2b Cohort 18 subjects; 10 had positive SPT to grass or ragweed allergens

2008 2b Randomized

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.