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Wise et al.

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Study Year LOE Study design Study groups Clinical endpoints Conclusion Harvey & Schocket 872

Antihistamines ketotifen, clemastine, and chlorpheniramine significantly inhibit skin

whealing responses. Sodium cromoglycate had no effect.

Hydroxyzine inhibited cutaneous wheal response to histamine. Cimetidine did not.

However, the 2 together produced significantly reduced whealing compared to either alone.

ICU stay, systemic steroid use, H2 blockers, and older age associated with negative histamine control test.

H1 antagonists impaired whealing responses within 3 days of discontinuation; tricyclic

antidepressants, benzodiazepines, mirtazapine, quetiapine had wheal suppression; other SSRIs and SNRIs as well as H2 antagonists were not independently associated with wheal suppression.

Histamine (10 mg/mL) SPT All subjects taking alprazolam had negative histamine SPT.

Chronic systemic steroid use reduces codeine induced wheal response but not histamine induced wheal response.

Phillips et al. 864 1983 2b Cohort Atopic subjects (n = 10) Inhibition of allergen-induced and histamine-induced wheals by local

intradermal antihistamine and cromoglycate injection.

1980 2b Cohort Healthy subjects (n = 10) Titrated intradermal histamine wheal before and after treatment with hydroxyzine, cimetidine, or both. Geng et al. 881 2015 3b Case-control 1 Cases with negative histamine control tests despite avoidance of antihistamine medications (n = 52); 2 Controls (n = 125) cohort

OR that multiple clinical variables including medication use predict negative histamine control test

SPT wheal area and SPT positivity as function of medication exposure and time since last dose

Intradermal skin test reactivity to codeine and histamine

1 Atopic patients with

chronic systemic steroid treatment (n = 25);

2 Atopic patients without

systemic steroid use (n = 25)

Histamine SPT responses in patients with variable exposure to a variety of medications

Duenas-Laita et al. 887 2009 4 Cohort Drug abusers taking alprazolam 2 mg TID (n = 42) Olson et al. 880 1990 4 Retrospective cohort

Shah et al. 886 2010 4 Retrospective

AR = allergic rhinitis; BID = twice a day; DBPCT = double-blind placebo controlled trial; ICU = intensive care unit; IgE = immunoglobulin E; LOE = level of evidence; OR = odds ratio; PAR = perennial allergic rhinitis; PO = per os (by mouth); RDBPCT = randomized double-blind placebo controlled trial; RDBT = randomized double blind trial; RPCT = randomized placebo controlled trial; SAR = seasonal allergic rhinitis; SNRI = selective norepinephrine reuptake inhibitor; SPT = skin-prick test; SSRI = selective serotonin reuptake inhibitor; TID = 3 times a day.

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.