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Wise et al.

Page 337

Female Serum tIgE (kU/L), Association with current HF (OR 1.7; 95% CI, 1.2–2.3). Serum tIgE (IU/mL), continuous variable Serum tIgE higher in AR (261) than in NAR (126), p < 0.01. Ando & Shima 892 2007 3b Cross-sectional School children (n = 98 with AR), 9–10 years old Serum tIgE levels (IU/mL) expressed as geometric means, continuous variable Kalpaklioglu et al. 894 2009 3b Retrospective case series Consecutive and unselected pts from a tertiary care clinic (n = 323,205 with AR); mean age 31.7 years continuous variable

Author Manuscript Author Manuscript Author Manuscript Author Manuscript

Serum tIgE higher in AR (230.4; 95% CI, 157.6–337.0) than in NAR (96.5; 95% CI, 76.9–121.1), p < 0.001

Study Year LOE Study design Study groups Endpoint Conclusion a Karli et al. 898 2013 3b Retrospective case series Serum tIgE (U/mL), continuous variable

tIgE <20 U/mL in 23.7%, tIgE 20-100 U/mL in 38.3%, tIgE >100 U/mL 33.8%. tIgE is a factor in confirming the diagnosis, but routine use is not recommended due to high cost and testing time.

Association with current HF (OR 1.9; 95% CI, 1.4–2.4).

Association with current HF (OR 2.1; 95% CI, 1.4–3.1).

Association with current HF (OR 2.2; 95% CI, 1.1–4.4).

Association with current HF (OR 1.9; 95% CI, 1.4–2.6).

Association with current HF (OR 2.1; 95% CI, 1.6–2.8).

Serum tIgE (kU/L),

continuous variable

Children (6–17 years) Serum tIgE >40.8 kU/L (median)

Serum tIgE (kU/L),

continuous variable

Adults (>18 years) Serum tIgE (kU/L),

continuous variable

Male Serum tIgE (kU/L),

continuous variable

Patients from otolaryngology clinic with at least 2 complaints of nasal itching, nasal

obstruction, rhinorrhea, and sneezing, and/or presumed AR (n = 295), mean age 33.9 years.

Salo et al. 454 2011 3b Cross-sectional 7398 subjects (>6 years) from NHANES 2005–2006.

a All reported ORs are adjusted unless differently specified and are reported with 95% CIs in parentheses. b The OR indicates an increase in the risk of current rhinitis/chronic RC per log unit increase of IgE levels. AR = allergic rhinitis; AUC = area under the curve; CI = confidence interval; HF = hay fever; IgE = Immunoglobulin E; LOE = level of evidence; MAAS = Manchester Asthma and Allergy Study; NAR = non-allergic rhinitis; NHANES = The National Health and Nutrition Examination Survey; NPV = negative predictive value; OR = odds ratio; PPV = positive predictive value; RC = rhinoconjunctivitis; SPT = skin prick test; tIgE = total immunoglobulin E; UnAdjOR = unadjusted odds ratio.

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.