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Wise et al.

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Author Manuscript Author Manuscript Author Manuscript Author Manuscript TABLE VIII.F.1-2. Evidence indicating a limited role for the use of total IgE in allergic rhinitis or allergy diagnosis Study Year LOE Study design Study groups Endpoint Conclusion Park et al. 902 2016 2b Prospective cohort 313 schoolchildren, 2-year follow-up study Initial examination: no allergic sensitization, serum tIgE <17.7 IU/mL No association with newly developed allergic nasal symptoms. Tu et al. 904 2013 2b Population-based cohort 1321 children (5-18 years) from PATCH study Serum tIgE (kU/L) AUC of serum tIgE for diagnosing rhinitis: 0.70. Serum tIgE >77.7 kU/L Sensitivity: 74.7%, specificity: 56.6%, PPV: 41.9%, NPV: 84.2% Serum tIgE >164.3 kU/L Sensitivity: 57.0%, specificity: 71.3%, PPV: 45.5%, NPV: 79.8% Serum tIgE >100 kU/L Sensitivity: 68.1%, specificity: 62.5%, PPV: 43.2%, NPV: 82.4% Insufficient diagnostic accuracy of serum tIgE levels to detect allergic diseases regardless of cutoff value used. Serum tIgE is linked more to atopy than directly to symptoms. Tay et al. 905 2016 3b Retrospective case series 352 patients with serum tIgE >1000 IU/mL attributable to atopic eczema, allergic bronchopulmonary aspergillosis, helminthic infection, and rare primary immunodeficiencies. (n = 84 with AR) serum tIgE (IU/mL) The elevated IgE level in AR is of limited diagnostic utility. Satwani et al. 903 2009 3b Cross-sectional 258 patients (6 months-12 years) from a Elevated serum tIgE No association of tIgE and AR (UnAdjOR 1.3; 95% CI, 0.8-2.2). Pediatric Medicine Unit (n = 172 with AR)

AR = allergic rhinitis; UnAdjOR = unadjusted odds ratio; AUC = area under the curve; CI = confidence interval; IgE = immunoglobulin E; LOE = level of evidence; NPV = negative predictive value; PATCH = Prediction of Allergies in Taiwanese Children; PPV = positive predictive value; tIgE = total immunoglobulin E.

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.