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Wise et al.

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Author Manuscript Author Manuscript Author Manuscript Author Manuscript TABLE VIII.F.2.

Evidence for the use of serum sIgE testing in the diagnosis of allergic rhinitis Study Year LOE Study design Study groups Clinical endpoint Conclusion Chinoy et al. 927 2005 3b Prospective cohort Patients with AR and/or bronchial asthma (n = 118) Compare skin test reactivity with serum sIgE antibodies For 4 indoor allergens, skin test was more sensitive than RAST. Skin test and RAST scores showed weak to moderate correlation. Pumhirun et al. 835 2000 3b Prospective cohort Perennial rhinitis patients Compared sensitivity and specificity of SPT to sIgE assay for D. pteronyssinus and D. farinae sIgE for D. pteronyssinus and D. farinae had sensitivity of 96.3% and 88.9% and specificity of 96.2% and 88.9%, respectively. This compared to sensitivity of 90.4% and 86.4% and specificity of 99.5% and 93.1% for SPT, respectively. Wood et al. 793 1999 3b Prospective cohort Patients with cat allergy determined by history and a cat-exposure model Compared the predictive values of SPT, IDT and RASTs in the diagnosis of cat allergy SPT and RAST values exhibited excellent efficiency in diagnosis of cat allergy. IDT added little to the diagnostic evaluation. Overall sensitivity and specificity of RAST was 69% and 100%, respectively. Tschopp et al. 822 1998 3b Prospective cohort Randomly selected sample of 8329 Swiss adults Compared the sensitivity, specificity, PPV and NPV of SPT, tIgE, and fluoroenzyme immunoassay in diagnosing AR Ferguson & Murray 926 1986 3b Prospective cohort 168 children with clinical suspicion of allergy to cats and/or dogs Compared the predictive values of skin tests and RASTs in children Ownby & Bailey 925 cohort Children age 4–19 years Diagnostic levels by MAST and RAST were compared to skin test cohort 1 34 patients with history of PR but negative SPT; with history of allergy to cats and/or dogs 1986 3b Prospective

Sensitivity of fluoroenzyme immunoassay was significantly higher than SPT and IgE. SPT was more specific and had a better PPV. SPT was the most efficient test to diagnose AR. RAST sensitivity and specificity was 71%-74% and 88%-90%, respectively. SPT sensitivity and specificity 68%-76% and 83%-86%, respectively.

MAST had a sensitivity of 59%, specificity of 97%, efficiency of 72%, compared with 67%, 97%, and 78%, respectively, for RAST. Neither MAST or RAST as sensitive as skin test.

Good agreement between SPT, RAST, and NPT. Poor agreement between positive IDT at 1:1000 concentration and SPT, RAST, and NP tests.

Good correlation between provocation tests and in vitro tests for allergy.

Seidman et al. 761 2015 5 Guideline Not applicable Not applicable Clinicians should perform and interpret or refer for sIgE (skin or blood) allergy testing for patients with a clinical diagnosis of AR who do not respond to empiric treatment or the diagnosis is uncertain. Bernstein et al. 818 2008 5 Review practice parameter

Not applicable Not applicable Sensitivity of sIgE ranges from 50% to 90% with an average of 70% to 75%. sIgE may be used along with history and

reactions for ragweed, grass, house dust, and mite

To determine the clinical relevance of positive intracutaneous test when epicutaneous test is negative

31 allergic patients AcR of minimal CSA of nasal cavity

2 19 patients with history PR and positive SPT;

3 Healthy controls

cohort

Reddy et al. 857 1978 3b Prospective

Wide et al. 911 1967 3b Prospective

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.