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Wise et al.

Page 343

LAR: Nasal sIgE to D. pteronyssinus detected in 25% immediately and at 24 hours, increase mast cells/eosinophils. Controls: Negative NPT, nasal sIgE, and other markers.

Author Manuscript Author Manuscript Author Manuscript Author Manuscript TABLE VIII.F.4.

NPT, nasal sIgE Nasal sIgE to Alternaria detected in 69% of positive NPT.

Evidence for nasal sIgE testing Study Year LOE Study design Study groups Clinical endpoint Conclusion Kim et al. 958 2016 2b Cross-sectional Collection technique: cotton ball. 1 NPT positive (n = 39); 2 NPT negative (n = 21)

NPT, nasal sIgE Nasal sIgE detected in all patients, no difference between NPT groups. No comparison pre- and post-NPT was performed.

Nasal sIgE AR with higher nasal sIgE to HDM than NAR, no difference between adults and children.

NPT, nasal sIgE LAR and AR common in elderly patients. 21% with LAR, 40.2% with AR, and 38.8% with NAR.

Nasal sIgE 93% had nasal sIgE, higher levels in sensitized subjects, correlation between nasal and serum sIgE. Nasal tIgE, sIgE, tryptase, eosinophil cationic protein, symptoms

Free light chains increased in AR and NAR nasal mucosa, suggesting role in hypersensitivity.

30% with nasal sIgE. LAR have local production of sIgE, mast cell/eosinophil activation.

Correlation between nasal and serum IgE only in children.

Nasal Ig free light chains

Nasal sIgE, sIgE,

tryptase, eosinophil cationic protein

Lee et al. 959 2016 2b Cross-sectional Collection technique: nasal lavage. 1 NAR, children (n = 12); 2 AR, children (n = 15); 3 NAR, adults (n = 9); 4 AR, adults (n = 15)

Sakaida et al. 960 2014 2b Cross-sectional Collection technique: suction of nasal secretions (n = 46 participants, 33 sensitized to allergen) Fuiano et al. 955 2011 2b Cross-sectional Collection technique: cellulose membrane. 1 Perennial AR, children (n = 20); 2 Perennial NAR, children (n = 36)

López et al. 306 2010 2b Cross-sectional Collection technique: nasal lavage. 1 LAR (n = 40); 2 Control (n = 50)

Powe et al. 950 2010 2b Cross-sectional Collection technique: cotton ball, immunohistochemistry. 1 AR (n = 90); 2 NARES (n = 90); 3 Control (n = 90) Rondon et al. 307 2009 2b Cross-sectional Collection technique: nasal lavage. 1 LAR (n = 30);

Bozek et al. 304 2015 2b Cross-sectional Collection technique: nasal lavage.Elderly patients, (n = 219)

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.