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Wise et al.

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Study Year LOE Study design Study groups Clinical endpoint Conclusion 2 Control (n = 30)

NPT, nasal sIgE Nasal sIgE to grass pollen detected in 35% NAR patients with positive NPT, and with similar sIgE profile as AR.

NPT, nasal sIgE Nasal sIgE to HDM detected in 22% of NAR patients with positive NPT.

Nasal sIgE Nasal sIgE to grass detected in 30% NAR. No nasal sIgE to HDM was detected. Nasal B and plasma cells with IgE

sIgE produced in nasal tissue of AR patients but not healthy controls.

sIgE to grass and HDM found in SAR and PAR subjects, respectively.

Allergen stimulates local class switching to IgE in the nasal mucosa.

Local IgE synthesis and cytokine regulation occur is the nasal mucosa of AR patients.

Nasal sIgE to grass and HDM

Nasal mRNA and gene transcripts

NPT, nasal IgE heavy chain

Rondon et al. 300 2008 2b Cross-sectional Collection technique: nasal lavage. 1 Seasonal NAR (n = 32); 2 AR to pollen (n = 35); 3 AR to HDM (n = 30); 4 Control (n = 50)

Rondon et al. 301 2007 2b Cross-sectional Collection technique: nasal lavage. 1 NAR (n = 50); 2 AR to HDM (n = 30); 3 Control (n = 30)

Powe et al. 284 2003 2b Cross-sectional Collection technique: mucosal biopsy. 1 NAR (n = 10); 2 AR (n = 11); 3 Control (n = 12)

KleinJan et al. 377 2000 2b Cross-sectional Collection technique: mucosal biopsy. 1 SAR (n = 12); 2 PAR (n = 16); 3 Control (n = 12)

KleinJan et al. 951 1997 2b Cross-sectional Collection technique: mucosal biopsy. 1 SAR (n = 11); 2 PAR (n = 10); 3 Control (n = 10) 1 AR (n = 12); nonconsecutive

2 Control (n = 4)

1 AR (n = 21)

Collection technique: mucosal biopsy.

Collection technique: mucosal biopsy.

nonconsecutive

Takhar et al. 312 2005 3b Cross-sectional,

Durham et al. 310 1997 3b Cross-sectional,

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.