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Wise et al.

Page 348

Author Manuscript Author Manuscript Author Manuscript Author Manuscript Study design Study groups Clinical endpoint Conclusion series

CD-sens correlates significantly with SPT, NPT, and IgE antibody concentration. CD-max (reactivity) did not correlate with any sensitization measures. CD-max varies substantially between patients and does not correlate to treatment or other allergy testing measures. Using CD-sens as a quantitative

measure of response to therapy or to complement other testing methods is more reliable.

CD-sens, SPT, NPT, IgE antibody concentration.

1 SAR to Timothy grass (n = 27) by clinical history, positive SPT, and sIgE; 2 Patients receiving anti-IgE for 4 years (n = 7)

Study Year LOE

Nopp et al. 975 2006 4 Case

AIT = allergen immunotherapy; AR = allergic rhinitis; BAT = basophil activation test; CD-sens = EC50 for allergen concentration inverted and multiplied by 100; HDM = house dust mite; IgE = immunoglobulin E; LAR = local allergic rhinitis; LOE = level of evidence; LTC4, LTD4, LTE4 = leukotriene C4, D4, E4; nPIF = nasal peak inspiratory flow; NPT = nasal provocation test; NPV = negative predictive value; PPV = positive predictive value; RCT = randomized controlled trial; ROC = receiver operating characteristic; SAR = seasonal allergic rhinitis; SCIT = subcutaneous immunotherapy; sIgE = specific immunoglobulin E; SLIT = sublingual immunotherapy.

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.