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Wise et al.

Page 351

In moderate-severe AR there was a significantly higher number of eosinophils ( p = 0.01), mast cells ( p = 0.001), neutrophils ( p = 0.046), and lymphocytes ( p = 0.001).

In patients with NARES, NARMA, and NARESMA there was a significantly higher rate of sneezing ( p < 0.01).

Author Manuscript Author Manuscript Author Manuscript Author Manuscript TABLE VIII.I-1. Study

Higher number of eosinophils ( p = 0.005) and mast cells ( p = 0.001) in polyallergy.

design Study groups Clinical endpoint Conclusion

NC eosinophil count High eosinophil count had an odds ratio of 1.14 (95% CI, 1.10-1.18) to identify AR. Association of cell counts with ARIA stage of disease

Comparison of NC cell counts

endoscopy according to type of rhinitis found on cytology

1 Monoallergic (n = 35);

2 Polyallergic (n = 48)

Di Lorenzo et al. 1092 2011 3b Cohort 1 AR (n = 1107); 2 NAR (n = 404) control

1 Mild (n = 30);

2 Moderate-severe (n = 32)

AR patients (n = 83):

AR patients (n = 62):

Gelardi 1099 2014 4 Cohort Patients with overlapping AR and NAR (n = 671) Sneezing in response to nasal

control

Studies assessing the diagnostic performance of nasal cytology Study Year LOE Gelardi et al. 1093 2015 3b Case Gelardi et al. 1094 2011 3b Case

AR = allergic rhinitis; ARIA = Allergic Rhinitis and its Impact on Asthma; CI = confidence interval; LOE = level of evidence; NAR = non-allergic rhinitis; NARES = non-allergic rhinitis with eosinophilia syndrome; NARESMA = non-allergic rhinitis with eosinophils and mast cells; NARMA = non-allergic rhinitis with mast cells; NC = nasal cytology.

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.