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Wise et al.

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Study Year LOE Study design Study groups Clinical endpoint Conclusion McConnell et al. 1136 No direct clinical endpoints, CR count and Bla g 2 CR allergen level

Decreased CR count and allergen concentration in insecticide bait treatment was low. Homes with

Professional extermination reduced CR numbers and median allergen levels by 80% to 90%.

CR allergen levels decreased within 6 months but returned or exceeded baseline levels by 12 months. Compliance with cleaning protocol was poor.

Treated homes had a significant decrease in number of CR compared to placebo, which

CR numbers eliminated in most inner-city homes with professionally applied insecticides. CR

allergen levels decreased by 78% to 93% over 8 months; mean allergen concentrations still above threshold of asthma morbidity.

high initial CR counts had larger reductions in Bla g 2 CR allergen concentration. Professional cleaning may help in homes with higher CR.

Cleaning solution did not add any improvements. Unclear if this level of reduction is sufficient to have clinical benefits.

continued for 6 months. Minimal reduction in Bla g 1 and Bla g 2 CR allergen. No significant difference: active vs placebo.

No direct clinical endpoints, CR count and Bla g 1 CR allergen level

No direct clinical endpoints, Bla g 1 CR allergen level

No direct clinical endpoints, CR counts and CR allergen levels Bla g 1 and Bla g 2

No direct clinical endpoints, CR counts and Bla g 1 CR allergen level

2003 1b RCT 1 Professional cleaning and insecticide bait traps;

2 Professional cleaning and bait traps with no insecticide; 3 No cleaning or bait traps

Wood et al. 1137 2001 1b RCT 1 Professional cleaning with sodium hypochlorite and insecticide bait traps; 2 Control without cleaning, extermination

1 Education-based intervention for parents: asthma triggers,

environmental controls; pest control; house cleaning; 2 Control

1 Bait traps with insecticide;

2 Identical-appearing placebo bait traps

Professional cleaning followed by pest control treatments

multi-city study

random, stratified,

placebo-controlled study control

Gergen et al. 1138 1999 1b RCT: Phase II of a Williams et al. 1140

1999 2b Single-blind, non

1999 3b Prospective case

Eggleston et al. 1139

CR = cockroach; HEPA = high-efficiency particulate air; LOE = level of evidence; RCT = randomized controlled trial; SR = systematic review.

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.