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Wise et al.

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Author Manuscript Author Manuscript Author Manuscript Author Manuscript TABLE IX.A.3. Study

design Study groups Clinical endpoint Conclusion

HEPA filters are associated with reduced airborne but not settled dust, cat allergen levels without effect on disease activity.

Avoidance recommendations may be impractical with high rates of sensitization, indirect exposure, and low rates of compliance.

Multimodality EC is associated with decreased allergen concentration and significant improvements in nasal inspiratory flow and patient symptoms.

Cat allergen levels (airborne and settled dust), symptom scores, medication scores, spirometry

Study Patients with diagnosed allergy Sensitization to household animals, compliance with avoidance recommendations and EC 2b a RCT Cat-allergic patients: 1 EC;

Environmental (settled dust) Fel d 1 levels, nasal inspiratory flow, nasal symptoms

Wood et al. 1148 1998 1b RCT Cat-sensitive adults: 1 HEPA filter; 2 Placebo

2 Unchanged environment

Evidence of the effectiveness of pet avoidance and environmental controls Study Year LOE Sanchez et al. 1146 2015 2b Cohort Björnsdottir et al. 1147 2003

a Follow-up <80% prevents 1b. EC = environmental control; HEPA = high-efficiency particulate air; LOE = level of evidence; RCT = randomized controlled trial.

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.